8xww

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Current revision (10:13, 22 January 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8xww is ON HOLD until Paper Publication
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==Crystal structure of the catalytic domain of human PDE5A complexed with 2-(3-chlorobenzyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylic acid==
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<StructureSection load='8xww' size='340' side='right'caption='[[8xww]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
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Authors: Zhang, F.C., Huang, Y.Y., Luo, H.B., Wu, Y.Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8xww]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XWW FirstGlance]. <br>
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Description: Crystal structure of the catalytic domain of human PDE5A complexed with 2-(3-chlorobenzyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylic acid
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.46&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1D5K:2-[(3-chlorophenyl)methyl]-4-oxidanylidene-3~{H}-quinazoline-7-carboxylic+acid'>A1D5K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Wu, Y.Y]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xww OCA], [https://pdbe.org/8xww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xww RCSB], [https://www.ebi.ac.uk/pdbsum/8xww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xww ProSAT]</span></td></tr>
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[[Category: Luo, H.B]]
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</table>
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[[Category: Huang, Y.Y]]
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== Function ==
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[[Category: Zhang, F.C]]
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[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Huang YY]]
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[[Category: Luo HB]]
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[[Category: Wu YY]]
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[[Category: Zhang FC]]

Current revision

Crystal structure of the catalytic domain of human PDE5A complexed with 2-(3-chlorobenzyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylic acid

PDB ID 8xww

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