9b2a

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Current revision (10:16, 22 January 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9b2a is ON HOLD until Paper Publication
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==Cryo-EM structure of the mouse TRPM3 alpha 2 channel in complex with the neurosteroid pregnenolone sulfate and the synthetic agonist CIM 0216==
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<StructureSection load='9b2a' size='340' side='right'caption='[[9b2a]], [[Resolution|resolution]] 3.82&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9b2a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9B2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9B2A FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.82&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6OU:[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl]+(~{Z})-octadec-9-enoate'>6OU</scene>, <scene name='pdbligand=A1AIB:(2~{S})-2-(3,4-dihydro-2~{H}-quinolin-1-yl)-~{N}-(5-methyl-1,2-oxazol-3-yl)-2-phenyl-ethanamide'>A1AIB</scene>, <scene name='pdbligand=A8W:[(3~{S},8~{S},9~{S},10~{R},13~{S},14~{S},17~{S})-17-ethanoyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1~{H}-cyclopenta[a]phenanthren-3-yl]+hydrogen+sulfate'>A8W</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9b2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9b2a OCA], [https://pdbe.org/9b2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9b2a RCSB], [https://www.ebi.ac.uk/pdbsum/9b2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9b2a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRPM3_MOUSE TRPM3_MOUSE] Constitutively active, non-selective divalent cation-conducting channel that is permeable to Ca(2+), Mn(2+), and Mg(2+), with a high permeability for Ca(2+) (PubMed:15824111, PubMed:20401728, PubMed:32780479). However, can be enhanced by increasing temperature and by ligands, including the endogenous neurosteroid pregnenolone sulfate and sphingosine-1 and suppressed by intracellular Mg(2+) (PubMed:20401728, PubMed:21555074). Implicated in a variety of cellular processes, including insulin/peptide secretion, vascular constriction and dilation, noxious heat sensing, inflammatory and spontaneous pain sensitivity (PubMed:21555074, PubMed:30853321, PubMed:33478988). In neurons of the dorsal root ganglia, functions as thermosensitive channel for the detection of noxious heat and spontaneous pain (PubMed:21555074, PubMed:33478988). Suggested to function as an ionotropic steroid receptor in beta-cell, indeed pregnenolone sulfate leads to Ca(2+) influx and enhanced insulin secretion (PubMed:18978782). Mediates Zn(2+) uptake into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion (PubMed:20401728). Forms heteromultimeric ion channels with TRPM1 which are permeable for Ca(2+) and Zn(2+) ions (By similarity). Exists as multiple splice variants which differ significantly in their biophysical properties (PubMed:15824111, PubMed:22961981).[UniProtKB:Q9HCF6]<ref>PMID:15824111</ref> <ref>PMID:18978782</ref> <ref>PMID:20401728</ref> <ref>PMID:21555074</ref> <ref>PMID:22961981</ref> <ref>PMID:30853321</ref> <ref>PMID:32780479</ref> <ref>PMID:33478988</ref> Displays strongly reduced permeability for divalent cations and high selectivity toward monovalent cations.<ref>PMID:15824111</ref> No channel activity.<ref>PMID:22961981</ref> No channel activity.<ref>PMID:22961981</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Borgnia MJ]]
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[[Category: Feng S]]
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[[Category: Guan Z]]
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[[Category: Im W]]
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[[Category: Lee S-Y]]
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[[Category: Park CG]]
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[[Category: Sharma K]]
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[[Category: Yin Y]]
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[[Category: Zhang F]]

Current revision

Cryo-EM structure of the mouse TRPM3 alpha 2 channel in complex with the neurosteroid pregnenolone sulfate and the synthetic agonist CIM 0216

PDB ID 9b2a

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