8w2e
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==SARS-CoV-2 M protein dimer in complex with JNJ-9676 and Fab-B== | |
| - | + | <StructureSection load='8w2e' size='340' side='right'caption='[[8w2e]], [[Resolution|resolution]] 3.06Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8w2e]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/SARS-CoV-2_pseudovirus SARS-CoV-2 pseudovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8W2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8W2E FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.06Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1AE8:(6S,8R)-N-(3-cyanophenyl)-5-{4-[difluoro(phenyl)methyl]phenyl}-6-methyl-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-3-carboxamide'>A1AE8</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8w2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8w2e OCA], [https://pdbe.org/8w2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8w2e RCSB], [https://www.ebi.ac.uk/pdbsum/8w2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8w2e ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VME1_SARS2 VME1_SARS2] Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins (By similarity). Regulates the localization of S protein at cis-Golgi, the place of virus budding (PubMed:33229438). May act by binding cytoplasmic c-terminus of S (PubMed:33229438).[HAMAP-Rule:MF_04202][PROSITE-ProRule:PRU01275]<ref>PMID:33229438</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: SARS-CoV-2 pseudovirus]] | ||
| + | [[Category: Van Damme E]] | ||
| + | [[Category: Yin Y]] | ||
Revision as of 06:17, 29 January 2025
SARS-CoV-2 M protein dimer in complex with JNJ-9676 and Fab-B
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