8y56

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'''Unreleased structure'''
 
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The entry 8y56 is ON HOLD until 2026-01-31
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==Cryo-EM reveals cholesterol binding in the lysosomal GPCR-like protein LYCHOS==
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<StructureSection load='8y56' size='340' side='right'caption='[[8y56]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8y56]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Y56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Y56 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.83&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=DKB:[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl]+octadecanoate'>DKB</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8y56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8y56 OCA], [https://pdbe.org/8y56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8y56 RCSB], [https://www.ebi.ac.uk/pdbsum/8y56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8y56 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LYCHS_HUMAN LYCHS_HUMAN] Cholesterol-binding protein that acts as a regulator of mTORC1 signaling pathway (PubMed:36007018). Acts as a sensor of cholesterol to signal cholesterol sufficiency to mTORC1: in presence of cholesterol, binds cholesterol, leading to disrupt interaction between the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:36007018). Upon cholesterol starvation, GPR155/LYCHOS is unable to perturb the association between GATOR1 and KICSTOR, leading to mTORC1 signaling inhibition (PubMed:36007018).<ref>PMID:36007018</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cholesterol plays a pivotal role in modulating the activity of mechanistic target of rapamycin complex 1 (mTOR1), thereby regulating cell growth and metabolic homeostasis. LYCHOS, a lysosome-localized G-protein-coupled receptor-like protein, emerges as a cholesterol sensor and is capable of transducing the cholesterol signal to affect the mTORC1 function. However, the precise mechanism by which LYCHOS recognizes cholesterol remains unknown. Here, using cryo-electron microscopy, we determined the three-dimensional structural architecture of LYCHOS in complex with cholesterol molecules, revealing a unique arrangement of two sequential structural domains. Through a comprehensive analysis of this structure, we elucidated the specific structural features of these two domains and their collaborative role in the process of cholesterol recognition by LYCHOS.
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Authors:
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Cryo-EM reveals cholesterol binding in the lysosomal GPCR-like protein LYCHOS.,Zhao J, Shen Q, Yong X, Li X, Tian X, Sun S, Xu Z, Zhang X, Zhang L, Yang H, Shao Z, Xu H, Jiang Y, Zhang Y, Yan W Nat Struct Mol Biol. 2025 Jan 17. doi: 10.1038/s41594-024-01470-9. PMID:39824976<ref>PMID:39824976</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 8y56" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Shao ZH]]
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[[Category: Shen QY]]
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[[Category: Zhang Y]]
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[[Category: Zhao J]]

Revision as of 06:19, 29 January 2025

Cryo-EM reveals cholesterol binding in the lysosomal GPCR-like protein LYCHOS

PDB ID 8y56

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