8umq

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Current revision (06:22, 5 February 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8umq is ON HOLD until Paper Publication
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==LSD1-CoREST in complex with T18, long soaking==
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<StructureSection load='8umq' size='340' side='right'caption='[[8umq]], [[Resolution|resolution]] 3.26&Aring;' scene=''>
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Authors: Caroli, J., Mattevi, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8umq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UMQ FirstGlance]. <br>
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Description: LSD1-CoREST in complex with T18, long soaking
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.26&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YAO:[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl+(2R,3S,4S)-5-[(1R,3S,3aS,13R)-3-(3-benzamidophenyl)-1-hydroxy-10,11-dimethyl-4,6-dioxo-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl+dihydrogen+diphosphate+(non-preferred+name)'>YAO</scene></td></tr>
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[[Category: Caroli, J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8umq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8umq OCA], [https://pdbe.org/8umq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8umq RCSB], [https://www.ebi.ac.uk/pdbsum/8umq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8umq ProSAT]</span></td></tr>
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[[Category: Mattevi, A]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RCOR1_HUMAN RCOR1_HUMAN] Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.<ref>PMID:11516394</ref> <ref>PMID:11171972</ref> <ref>PMID:12032298</ref> <ref>PMID:12399542</ref> <ref>PMID:12493763</ref> <ref>PMID:16140033</ref> <ref>PMID:16079794</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Caroli J]]
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[[Category: Mattevi A]]

Current revision

LSD1-CoREST in complex with T18, long soaking

PDB ID 8umq

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