1ykb

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(New page: 200px<br /> <applet load="1ykb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ykb, resolution 2.60&Aring;" /> '''Crystal Structure o...)
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Revision as of 18:14, 12 November 2007

Image:1ykb.gif

1ykb, resolution 2.60Å

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Crystal Structure of Insect Cell Expressed IL-22

Overview

The crystal structure of interleukin-22 expressed in Drosophila, melanogaster S2 cells (IL-22(Dm)) has been determined at 2.6 A resolution., IL-22(Dm) crystals contain six molecules in the asymmetric unit., Comparison of IL-22(Dm) and IL-22(Ec) (interleukin-22 produced in, Escherichia coli) structures reveals that N-linked glycosylation causes, only minor structural changes to the cytokine. However, 1-4 A main-chain, differences are observed between the six IL-22(Dm) monomers at regions, corresponding to the IL-22R1 and IL-10R2 binding sites. The structure of, the carbohydrate and the conformational variation of IL22(Dm) provide new, insights into IL-22 receptor recognition.

About this Structure

1YKB is a Single protein structure of sequence from Homo sapiens with NAG as ligand. Full crystallographic information is available from OCA.

Reference

Structure of insect-cell-derived IL-22., Xu T, Logsdon NJ, Walter MR, Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):942-50. Epub 2005, Jun 24. PMID:15983417

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