1v4b

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[[Image:1v4b.gif|left|200px]]
[[Image:1v4b.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1v4b |SIZE=350|CAPTION= <scene name='initialview01'>1v4b</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1v4b", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Azobenzene_reductase Azobenzene reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.1.6 1.7.1.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1v4b| PDB=1v4b | SCENE= }}
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|RELATEDENTRY=[[1v4c|1V4C]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v4b OCA], [http://www.ebi.ac.uk/pdbsum/1v4b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1v4b RCSB]</span>
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}}
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'''The crystal structure of AzoR (Azo Reductase) from Escherichia coli: Oxidized form'''
'''The crystal structure of AzoR (Azo Reductase) from Escherichia coli: Oxidized form'''
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[[Category: Ito, K.]]
[[Category: Ito, K.]]
[[Category: Tanokura, M.]]
[[Category: Tanokura, M.]]
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[[Category: azo reductase]]
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[[Category: Azo reductase]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:03:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:19:20 2008''
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Revision as of 09:03, 3 May 2008

Image:1v4b.gif

Template:STRUCTURE 1v4b

The crystal structure of AzoR (Azo Reductase) from Escherichia coli: Oxidized form


Overview

The crystal structure of AzoR (azoreductase) has been determined in complex with FMN for two different crystal forms at 1.8 and 2.2 A resolution. AzoR is an oxidoreductase isolated from Escherichia coli as a protein responsible for the degradation of azo compounds. This enzyme is an FMN-dependent NADH-azoreductase and catalyzes the reductive cleavage of azo groups by a ping-pong mechanism. The structure suggests that AzoR acts in a homodimeric state forming the two identical catalytic sites to which both monomers contribute. The structure revealed that each monomer of AzoR has a flavodoxin-like structure, without the explicit overall amino acid sequence homology. Superposition of the structures from the two different crystal forms revealed the conformational change and suggested a mechanism for accommodating substrates of different size. Furthermore, comparison of the active site structure with that of NQO1 complexed with substrates provides clues to the possible substrate-binding mechanism of AzoR.

About this Structure

1V4B is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of AzoR from Escherichia coli. An oxidereductase conserved in microorganisms., Ito K, Nakanishi M, Lee WC, Sasaki H, Zenno S, Saigo K, Kitade Y, Tanokura M, J Biol Chem. 2006 Jul 21;281(29):20567-76. Epub 2006 May 9. PMID:16684776 Page seeded by OCA on Sat May 3 12:03:42 2008

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