8yei
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==HPV18 L1 pentamer in complex with Fab F5-203== | |
| - | + | <StructureSection load='8yei' size='340' side='right'caption='[[8yei]], [[Resolution|resolution]] 2.93Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8yei]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_papillomavirus_type_18 Human papillomavirus type 18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YEI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YEI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.93Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yei OCA], [https://pdbe.org/8yei PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yei RCSB], [https://www.ebi.ac.uk/pdbsum/8yei PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yei ProSAT]</span></td></tr> |
| - | [[Category: Fu | + | </table> |
| - | [[Category: Wang | + | == Function == |
| + | [https://www.uniprot.org/uniprot/Q5G245_HPV18 Q5G245_HPV18] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[RuleBase:RU361248] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Human papillomavirus type 18]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Fu W]] | ||
| + | [[Category: Wang X]] | ||
Current revision
HPV18 L1 pentamer in complex with Fab F5-203
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