9ejp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "9ejp" [edit=sysop:move=sysop])
Current revision (19:08, 26 February 2025) (edit) (undo)
 
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 9ejp is ON HOLD
+
==Crystal structure of WDR91 in complex with XS838489==
-
 
+
<StructureSection load='9ejp' size='340' side='right'caption='[[9ejp]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
-
Authors: Zeng, H., Ahmad, H., Wang, X., Sun, J., Dong, A., Seitova, A., Arrowsmith, C.H., Edwards, A.M., Peng, H., Halabelian, L., Structural Genomics Consortium (SGC)
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[9ejp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EJP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EJP FirstGlance]. <br>
-
Description: Crystal structure of WDR91 in complex with XS838489
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BIW:~{N}-[(5~{R})-1,1-bis(oxidanylidene)-2,3,4,5-tetrahydro-1$l^{6}-benzothiepin-5-yl]-2-oxidanyl-quinoxaline-6-carboxamide'>A1BIW</scene></td></tr>
-
[[Category: Zeng, H]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ejp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ejp OCA], [https://pdbe.org/9ejp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ejp RCSB], [https://www.ebi.ac.uk/pdbsum/9ejp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ejp ProSAT]</span></td></tr>
-
[[Category: Arrowsmith, C.H]]
+
</table>
-
[[Category: Peng, H]]
+
== Function ==
-
[[Category: Structural Genomics Consortium (Sgc)]]
+
[https://www.uniprot.org/uniprot/WDR91_HUMAN WDR91_HUMAN] Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity).[UniProtKB:Q7TMQ7]<ref>PMID:26783301</ref> <ref>PMID:27126989</ref>
-
[[Category: Halabelian, L]]
+
== References ==
-
[[Category: Sun, J]]
+
<references/>
-
[[Category: Seitova, A]]
+
__TOC__
-
[[Category: Ahmad, H]]
+
</StructureSection>
-
[[Category: Wang, X]]
+
[[Category: Homo sapiens]]
-
[[Category: Dong, A]]
+
[[Category: Large Structures]]
-
[[Category: Edwards, A.M]]
+
[[Category: Ahmad H]]
 +
[[Category: Arrowsmith CH]]
 +
[[Category: Dong A]]
 +
[[Category: Edwards AM]]
 +
[[Category: Halabelian L]]
 +
[[Category: Peng H]]
 +
[[Category: Seitova A]]
 +
[[Category: Sun J]]
 +
[[Category: Wang X]]
 +
[[Category: Zeng H]]

Current revision

Crystal structure of WDR91 in complex with XS838489

PDB ID 9ejp

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/9ejp"
Personal tools