9k7b

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Current revision (19:23, 26 February 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9k7b is ON HOLD until 2026-10-23
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==Cryo-EM structure of human taurine transporter TauT bound with taurine molecules in an inward-open state in the saposin-disc==
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<StructureSection load='9k7b' size='340' side='right'caption='[[9k7b]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9k7b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9K7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9K7B FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TAU:2-AMINOETHANESULFONIC+ACID'>TAU</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9k7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9k7b OCA], [https://pdbe.org/9k7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9k7b RCSB], [https://www.ebi.ac.uk/pdbsum/9k7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9k7b ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SC6A6_HUMAN SC6A6_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/SC6A6_HUMAN SC6A6_HUMAN] Mediates sodium- and chloride-dependent transport of taurine (PubMed:31345061, PubMed:31903486, PubMed:8010975, PubMed:8382624, PubMed:8654117). Mediates transport of beta-alanine (PubMed:8010975). Can also mediate transport of hypotaurine and gamma-aminobutyric acid (GABA) (By similarity).[UniProtKB:O35316]<ref>PMID:31345061</ref> <ref>PMID:31903486</ref> <ref>PMID:8010975</ref> <ref>PMID:8382624</ref> <ref>PMID:8654117</ref> Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.<ref>PMID:31345061</ref> <ref>PMID:31903486</ref> <ref>PMID:8382624</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Xu EH]]
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[[Category: Zhang H]]

Current revision

Cryo-EM structure of human taurine transporter TauT bound with taurine molecules in an inward-open state in the saposin-disc

PDB ID 9k7b

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OCA

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