1ypz

From Proteopedia

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Revision as of 18:16, 12 November 2007

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spinqualitylabelsall models 1ypz, resolution 3.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Immune receptor

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Gammadelta T cell receptors (TCRs), alphabeta TCRs, and antibodies are the, three lineages of somatically recombined antigen receptors. The structural, basis for ligand recognition is well defined for alphabeta TCR and, antibodies but is lacking for gammadelta TCRs. We present the 3.4 A, structure of the murine gammadelta TCR G8 bound to its major, histocompatibility complex (MHC) class Ib ligand, T22. G8 predominantly, uses germline-encoded residues of its delta chain, complementarity-determining region 3 (CDR3) loop to bind T22 in an, orientation substantially different from that seen in alphabeta, TCR/peptide-MHC. That junctionally encoded G8 residues play an ancillary, role in binding suggests a fusion of innate and adaptive recognition, strategies.

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

1YPZ is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22., Adams EJ, Chien YH, Garcia KC, Science. 2005 Apr 8;308(5719):227-31. PMID:15821084

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