1yrk

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(New page: 200px<br /> <applet load="1yrk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1yrk, resolution 1.70&Aring;" /> '''The C2 Domain of PK...)
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Revision as of 18:17, 12 November 2007

Image:1yrk.gif

1yrk, resolution 1.70Å

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The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain

Overview

In this issue of Cell, report that the C2 domain of the serine/threonine, protein kinase Cdelta is a phosphotyrosine binding domain and present the, crystal structure of this C2 domain bound to a peptide containing, phosphotyrosine. Prior to this work, C2 domains were thought to bind only, to phospholipids or to unphosphorylated proteins, and the SH2 and PTB, domains were the only signaling domains known to recognize, phosphotyrosine. This new role for the C2 domain links phosphotyrosine, recognition directly to serine/threonine kinase activity and reveals an, unexpected mechanism for crosstalk between distinct signaling pathways.

About this Structure

1YRK is a Single protein structure of sequence from Homo sapiens with ACY as ligand. Full crystallographic information is available from OCA.

Reference

C2 can do it, too., Sondermann H, Kuriyan J, Cell. 2005 Apr 22;121(2):158-60. PMID:15851022

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