8yg7

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Current revision (10:23, 12 March 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8yg7 is ON HOLD until 2026-02-26
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==HSA Copper Indomethacin Complex==
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<StructureSection load='8yg7' size='340' side='right'caption='[[8yg7]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
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Authors: Zhang, Z.L., Yang, F.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8yg7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YG7 FirstGlance]. <br>
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Description: HSA Copper Indomethacin Complex
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1D6U:~{N},~{N}-dimethyl-7-propan-2-yl-3-thia-5-aza-1,6-diazonia-2$l^{3}-cupratricyclo[6.4.0.0^{2,6}]dodeca-1(12),4,6,8,10-pentaen-4-amine'>A1D6U</scene>, <scene name='pdbligand=IMN:INDOMETHACIN'>IMN</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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[[Category: Yang, F]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yg7 OCA], [https://pdbe.org/8yg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yg7 RCSB], [https://www.ebi.ac.uk/pdbsum/8yg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yg7 ProSAT]</span></td></tr>
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[[Category: Zhang, Z.L]]
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Yang F]]
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[[Category: Zhang ZL]]

Current revision

HSA Copper Indomethacin Complex

PDB ID 8yg7

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