8yw8

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Current revision (10:23, 12 March 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8yw8 is ON HOLD until 2026-03-30
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==Cryo-EM structure of human mitochondrial pyruvate carrier in complex with the inhibitor UK5099==
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<StructureSection load='8yw8' size='340' side='right'caption='[[8yw8]], [[Resolution|resolution]] 3.17&Aring;' scene=''>
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Authors: Shi, J.H., Liang, J.M., Ma, D.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8yw8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YW8 FirstGlance]. <br>
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Description: Cryo-EM structure of human mitochondrial pyruvate carrier in complex with the inhibitor UK5099
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.17&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=I2R:(~{E})-2-cyano-3-(1-phenylindol-3-yl)prop-2-enoic+acid'>I2R</scene></td></tr>
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[[Category: Liang, J.M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yw8 OCA], [https://pdbe.org/8yw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yw8 RCSB], [https://www.ebi.ac.uk/pdbsum/8yw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yw8 ProSAT]</span></td></tr>
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[[Category: Ma, D]]
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</table>
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[[Category: Shi, J.H]]
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== Function ==
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[https://www.uniprot.org/uniprot/MPC2_HUMAN MPC2_HUMAN] Mediates the uptake of pyruvate into mitochondria.<ref>PMID:22628558</ref> <ref>PMID:26253029</ref> <ref>PMID:27317664</ref> <ref>PMID:29472561</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Liang JM]]
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[[Category: Ma D]]
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[[Category: Shi JH]]

Current revision

Cryo-EM structure of human mitochondrial pyruvate carrier in complex with the inhibitor UK5099

PDB ID 8yw8

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