9ax5

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Current revision (10:26, 12 March 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9ax5 is ON HOLD until Paper Publication
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==Cryo-EM structure of Phospholipase C epsilon PH-C terminus in complex with RhoA-GTP==
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<StructureSection load='9ax5' size='340' side='right'caption='[[9ax5]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9ax5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9AX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9AX5 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ax5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ax5 OCA], [https://pdbe.org/9ax5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ax5 RCSB], [https://www.ebi.ac.uk/pdbsum/9ax5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ax5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PLCE1_RAT PLCE1_RAT] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downtream of AVIL to allow ARP2/3 complex assembly (By similarity).[UniProtKB:Q9P212]<ref>PMID:12721365</ref> <ref>PMID:16314422</ref> <ref>PMID:17086182</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Rattus norvegicus]]
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[[Category: Lyon AM]]
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[[Category: Ohri V]]

Current revision

Cryo-EM structure of Phospholipase C epsilon PH-C terminus in complex with RhoA-GTP

PDB ID 9ax5

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