9ect
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the Gemella haemolysans Immunoglobulin A1 Protease Trypsin-Like Domain== | |
| + | <StructureSection load='9ect' size='340' side='right'caption='[[9ect]], [[Resolution|resolution]] 1.75Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[9ect]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gemella_haemolysans Gemella haemolysans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ECT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ECT FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ect FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ect OCA], [https://pdbe.org/9ect PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ect RCSB], [https://www.ebi.ac.uk/pdbsum/9ect PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ect ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/C5NYF3_9BACL C5NYF3_9BACL] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Immunoglobulin A (IgA) proteases are a group of bacterial-derived enzymes that selectivity hydrolyze human IgA in the hinge region that is unique to this immunoglobulin. Several IgA protease (IgAP) families have evolved this ability using both metalloprotease and serine protease chemical mechanisms. One family of metal-dependent IgAPs is the M26 family. This family can be grouped into two subfamilies based upon the presence or absence of a trypsin-like domain found N-terminal to the IgAP domain. The role of this domain in IgAP structure and function is poorly understood. Here, we present the first structural characterization of an M26 IgAP trypsin-like domain from Gemella haemolysans (GhTrp). These structural data demonstrate that the GhTrp domain possesses a trypsin-like fold but contains significant deviations in the surface-loop structure that is known to be coupled to protease selectivity. The lack of observable catalytic function coupled with the structural data suggest that this domain may exist in a pro-enzyme-like state that can potentially be activated when the domain is N-terminally proteolytically excised from the larger M26 IgAP structure. | ||
| - | + | The structure of the Gemella haemolysans M26 IgA1 protease trypsin-like domain.,Tran N, Redzic JS, Eisenmesser EZ, Holyoak T Acta Crystallogr F Struct Biol Commun. 2025 Apr 1. doi: , 10.1107/S2053230X25001219. PMID:40019192<ref>PMID:40019192</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 9ect" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gemella haemolysans]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Holyoak T]] | ||
| + | [[Category: Tran N]] | ||
Current revision
Crystal Structure of the Gemella haemolysans Immunoglobulin A1 Protease Trypsin-Like Domain
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