9n55
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==X-ray Crystallographic Structure of Lipid-bound Orf9b Homodimer== | |
| - | + | <StructureSection load='9n55' size='340' side='right'caption='[[9n55]], [[Resolution|resolution]] 1.65Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9n55]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9N55 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9N55 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OCT:N-OCTANE'>OCT</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9n55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9n55 OCA], [https://pdbe.org/9n55 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9n55 RCSB], [https://www.ebi.ac.uk/pdbsum/9n55 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9n55 ProSAT]</span></td></tr> |
| - | [[Category: Fraser | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ORF9B_SARS2 ORF9B_SARS2] Plays a role in inhibiting the host innate immune response by targeting the mitochondrial-associated innate immune response. Acts by binding to host TOMM70, inhibiting its binding to HSP90AB1 thereby disrupting the interferon activation pathway.<ref>PMID:32728199</ref> <ref>PMID:34502139</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Severe acute respiratory syndrome coronavirus 2]] | ||
| + | [[Category: Fraser JS]] | ||
| + | [[Category: San Felipe CJ]] | ||
Current revision
X-ray Crystallographic Structure of Lipid-bound Orf9b Homodimer
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