9jvz

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m (Protected "9jvz" [edit=sysop:move=sysop])
Current revision (06:36, 19 March 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9jvz is ON HOLD
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==CryoEM structure of M. tuberculosis ClpP1P2 bound to bortezomib==
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<StructureSection load='9jvz' size='340' side='right'caption='[[9jvz]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
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Authors: Zhou, B., Zhao, H., Gao, Y., Chen, W., Zhang, T., He, J., Xiong, X.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9jvz]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JVZ FirstGlance]. <br>
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Description: CryoEM structure of M. tuberculosis ClpP1P2 bound to bortezomib
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.56&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BO2:N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE'>BO2</scene></td></tr>
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[[Category: Zhou, B]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jvz OCA], [https://pdbe.org/9jvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jvz RCSB], [https://www.ebi.ac.uk/pdbsum/9jvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jvz ProSAT]</span></td></tr>
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[[Category: Gao, Y]]
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</table>
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[[Category: Chen, W]]
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== Function ==
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[[Category: Xiong, X]]
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[https://www.uniprot.org/uniprot/CLPP1_MYCTU CLPP1_MYCTU] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity).
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[[Category: Zhao, H]]
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__TOC__
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[[Category: Zhang, T]]
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</StructureSection>
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[[Category: He, J]]
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Chen W]]
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[[Category: Gao Y]]
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[[Category: He J]]
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[[Category: Xiong X]]
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[[Category: Zhang T]]
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[[Category: Zhao H]]
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[[Category: Zhou B]]

Current revision

CryoEM structure of M. tuberculosis ClpP1P2 bound to bortezomib

PDB ID 9jvz

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OCA

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