9l2f

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Current revision (06:37, 19 March 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9l2f is ON HOLD until Paper Publication
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==Structure of SARM1 bound to M1 and 1AD in the active state==
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<StructureSection load='9l2f' size='340' side='right'caption='[[9l2f]], [[Resolution|resolution]] 3.55&Aring;' scene=''>
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Authors: Huang, Y., Zhang, J., Zheng, S., Wang, X.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9l2f]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9L2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9L2F FirstGlance]. <br>
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Description: Structure of SARM1 bound to M1 and 1AD in the active state
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.55&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EIV:[(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(3-sulfanylpyridin-1-ium-1-yl)oxolan-2-yl]methyl+dihydrogen+phosphate'>A1EIV</scene></td></tr>
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[[Category: Wang, X]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9l2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9l2f OCA], [https://pdbe.org/9l2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9l2f RCSB], [https://www.ebi.ac.uk/pdbsum/9l2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9l2f ProSAT]</span></td></tr>
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[[Category: Zheng, S]]
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</table>
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[[Category: Zhang, J]]
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== Function ==
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[[Category: Huang, Y]]
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[https://www.uniprot.org/uniprot/SARM1_HUMAN SARM1_HUMAN] Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.<ref>PMID:15123841</ref> <ref>PMID:16964262</ref> <ref>PMID:16985498</ref> <ref>PMID:20306472</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Huang Y]]
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[[Category: Wang X]]
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[[Category: Zhang J]]
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[[Category: Zheng S]]

Current revision

Structure of SARM1 bound to M1 and 1AD in the active state

PDB ID 9l2f

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