9n80
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human HRSP12== | |
| - | + | <StructureSection load='9n80' size='340' side='right'caption='[[9n80]], [[Resolution|resolution]] 1.39Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9n80]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9N80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9N80 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.39Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9n80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9n80 OCA], [https://pdbe.org/9n80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9n80 RCSB], [https://www.ebi.ac.uk/pdbsum/9n80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9n80 ProSAT]</span></td></tr> |
| - | [[Category: Mugridge | + | </table> |
| - | [[Category: | + | == Function == |
| + | [https://www.uniprot.org/uniprot/RIDA_HUMAN RIDA_HUMAN] Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.<ref>PMID:20817725</ref> <ref>PMID:22094463</ref> Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex (PubMed:30930054, PubMed:8973653). Acts by bridging YTHDF2 and the ribonuclease P/MRP complex (PubMed:30930054). RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage (PubMed:30930054).<ref>PMID:30930054</ref> <ref>PMID:8973653</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mugridge JS]] | ||
| + | [[Category: Suma K]] | ||
Current revision
Crystal structure of human HRSP12
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