Cytochrome P450 3D structures

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Current revision (08:38, 24 March 2025) (edit) (undo)
 
Line 8: Line 8:
**[[2hi4]] – hP4501A2+naphthoflavone - human<br />
**[[2hi4]] – hP4501A2+naphthoflavone - human<br />
**[[4i8v]] - hP4501A1 +naphthoflavone<br />
**[[4i8v]] - hP4501A1 +naphthoflavone<br />
-
**[[6dwn]] - hP4501A1 + erlotinib<br />
+
**[[6dwn]], [[6udl]], [[6udm]] - hP4501A1 + drug<br />
**[[6dwm]] - hP4501A1 + bergamottin<br />
**[[6dwm]] - hP4501A1 + bergamottin<br />
**[[3pm0]], [[6oyu]] - hP4501B1+naphthoflavone<br />
**[[3pm0]], [[6oyu]] - hP4501B1+naphthoflavone<br />
Line 19: Line 19:
**[[1pq2]] - hP4502C8<br />
**[[1pq2]] - hP4502C8<br />
**[[1og2]], [[1og5]] – hP4502C9 (mutant)<br />
**[[1og2]], [[1og5]] – hP4502C9 (mutant)<br />
-
**[[7rl2]] – hP4502C9 (mutant)) + drug <br />
 
**[[4gqs]] - hP4502C19 catalytic domain<br />
**[[4gqs]] - hP4502C19 catalytic domain<br />
**[[2f9q]], [[3qm4]] – hP4502D6<br />
**[[2f9q]], [[3qm4]] – hP4502D6<br />
Line 54: Line 53:
**[[5a5i]], [[5a5j]], [[5w0c]], [[5k7k]] - hP4502C9 + inhibitor<br />
**[[5a5i]], [[5a5j]], [[5w0c]], [[5k7k]] - hP4502C9 + inhibitor<br />
**[[4nz2]] - hP4502C9 (mutant) + inhibitor<br />
**[[4nz2]] - hP4502C9 (mutant) + inhibitor<br />
 +
**[[6vlt]], [[7rl2]], [[8vx0]], [[8vz7]] – hP4502C9 (mutant) + drug <br />
**[[3tbg]], [[4wnw]] – hP4502D6 + thioridazine<br />
**[[3tbg]], [[4wnw]] – hP4502D6 + thioridazine<br />
**[[6csb]] - hP4502D6 (mutant) + thioridazine<br />
**[[6csb]] - hP4502D6 (mutant) + thioridazine<br />
Line 71: Line 71:
**[[1tqn]], [[1w0e]], [[1w0f]], [[1w0g]] – hP4503A4<br />
**[[1tqn]], [[1w0e]], [[1w0f]], [[1w0g]] – hP4503A4<br />
**[[5vcc]], [[5vcd]], [[4l3q]] - hP4503A4 (mutant) <br />
**[[5vcc]], [[5vcd]], [[4l3q]] - hP4503A4 (mutant) <br />
-
**[[2v0m]] – hP4503A4+ anti-fungal drug<br />
+
**[[2v0m]], [[8spd]] – hP4503A4+ anti-fungal drug<br />
**[[2j0d]] - hP4503A4+ antibiotic<br />
**[[2j0d]] - hP4503A4+ antibiotic<br />
**[[3nxu]], [[3tjs]] - hP4503A4+ anti-HIV drug<br />
**[[3nxu]], [[3tjs]] - hP4503A4+ anti-HIV drug<br />
Line 79: Line 79:
**[[3ua1]] - hP4503A4 + ergocryptine<br />
**[[3ua1]] - hP4503A4 + ergocryptine<br />
**[[5vcg]] - hP4503A4 (mutant) + ergocryptine<br />
**[[5vcg]] - hP4503A4 (mutant) + ergocryptine<br />
-
**[[4ny4]], [[4d7d]], [[4d78]], [[4d75]], [[4d6z]], [[6bdm]], [[6bdk]], [[6bdi]], [[6bdh]], [[6bd8]], [[6bd7]], [[6bd6]], [[6bd5]], [[6bcz]], [[6ma8]], [[6ma7]], [[6ma6]], [[6dal]], [[6daj]], [[6dag]], [[6dac]], [[6dab]], [[6daa]], [[6da8]], [[6da5]], [[6da3]], [[6da2]], [[6une]], [[6ung]], [[6unh]], [[6uni]], [[6unj]], [[6unk]], [[6unl]], [[6unm]], [[7ks8]], [[7ksa]], [[7ksh]], [[7kvh]], [[7kvi]], [[7kvj]], [[7kvn]], [[7kvo]], [[7kvs]], [[7uay]], [[7uaz]], [[7uf9]], [[7ufb]], [[7ufc]], [[7ufd]], [[7ufe]], [[7uff]] - hP4503A4 + inhibitor <br />
+
**[[4ny4]], [[4d7d]], [[4d78]], [[4d75]], [[4d6z]], [[6bdm]], [[6bdk]], [[6bdi]], [[6bdh]], [[6bd8]], [[6bd7]], [[6bd6]], [[6bd5]], [[6bcz]], [[6ma8]], [[6ma7]], [[6ma6]], [[6dal]], [[6daj]], [[6dag]], [[6dac]], [[6dab]], [[6daa]], [[6da8]], [[6da5]], [[6da3]], [[6da2]], [[6une]], [[6ung]], [[6unh]], [[6uni]], [[6unj]], [[6unk]], [[6unl]], [[6unm]], [[7ks8]], [[7ksa]], [[7ksh]], [[7kvh]], [[7kvi]], [[7kvj]], [[7kvn]], [[7kvo]], [[7kvs]], [[7uay]], [[7uaz]], [[7uf9]], [[7ufa]], [[7ufb]], [[7ufc]], [[7ufd]], [[7ufe]], [[7uff]], [[8dyc]], [[8ewd]], [[8ewe]], [[8ewl]], [[8ewm]], [[8ewn]], [[8ewp]], [[8ewq]], [[8ewr]], [[8ews]], [[8exb]], [[9bbb]], [[9cor]], [[9cos]], [[9cot]], [[9cou]], [[9cov]], [[9cow]], [[9cox]], [[9coy]] - hP4503A4 + inhibitor <br />
**[[5te8]] - hP4503A4 + sedation drug <br />
**[[5te8]] - hP4503A4 + sedation drug <br />
**[[5a1p]], [[5a1r]] - hP4503A4 + progesterone <br />
**[[5a1p]], [[5a1r]] - hP4503A4 + progesterone <br />
**[[7lxl]] - hP4503A4 + testosterone <br />
**[[7lxl]] - hP4503A4 + testosterone <br />
 +
**[8so1l]], [[8so2]] - hP4503A4 + caffeine <br />
**[[6mjm]] - hP4503A5 <br />
**[[6mjm]] - hP4503A5 <br />
**[[5veu]], [[7sv2]] - hP4503A5 + inhibitor<br />
**[[5veu]], [[7sv2]] - hP4503A5 + inhibitor<br />
 +
**[[8sg5]]] - hP4503A5 + clotrimazole<br />
**[[7lad]] - hP4503A7 + drug<br />
**[[7lad]] - hP4503A7 + drug<br />
**[[7mk8]] - hP4503A7 + dithiothreitol<br />
**[[7mk8]] - hP4503A7 + dithiothreitol<br />
 +
**[[8gk3]] - hP4503A7 + substrate<br />
* human P450 7 family
* human P450 7 family
Line 105: Line 108:
**[[4nkv]], [[6wr1]] - hP450 C17 (mutant) + abiraterone derivative<br />
**[[4nkv]], [[6wr1]] - hP450 C17 (mutant) + abiraterone derivative<br />
**[[5irq]] - hP450 C17 + orteronel<br />
**[[5irq]] - hP450 C17 + orteronel<br />
-
**[[5irv]] - hP450 C17 + inhibitor<br />
+
**[[5irv]], [[8fda]] - hP450 C17 + inhibitor<br />
**[[4nkw]], [[4nkz]] - hP450 C17 (mutant) + pregnenolone derivative<br />
**[[4nkw]], [[4nkz]] - hP450 C17 (mutant) + pregnenolone derivative<br />
**[[4nkx]], [[4nky]] - hP450 C17 (mutant) + progesterone derivative<br />
**[[4nkx]], [[4nky]] - hP450 C17 (mutant) + progesterone derivative<br />
Line 136: Line 139:
**[[2ij7]] - MtP450 CYP121+fluconazole<br />
**[[2ij7]] - MtP450 CYP121+fluconazole<br />
**[[1n4g]], [[4ktf]], [[4ktj]], [[4ktk]], [[4ktl]], [[6geo]], [[6geq]] - MtP450 CYP121+pyrazole derivative<br />
**[[1n4g]], [[4ktf]], [[4ktj]], [[4ktk]], [[4ktl]], [[6geo]], [[6geq]] - MtP450 CYP121+pyrazole derivative<br />
-
**[[4ict]], [[4ips]], [[4ipw]], [[4iq7]], [[4iq9]], [[5wp2]] - MtP450 CYP121 + piperazine derivative<br />
+
**[[4ict]], [[4ips]], [[4ipw]], [[4iq7]], [[4iq9]], [[5wp2]], [[8tdp]], [[8tdq]] - MtP450 CYP121 + piperazine derivative<br />
**[[6upg]], [[6upi]] - MtP450 CYP121 + cyf-4-ome<br />
**[[6upg]], [[6upi]] - MtP450 CYP121 + cyf-4-ome<br />
**[[6rq0]], [[6rq1]], [[6rq3]], [[6rq5]], [[6rq6]], [[6rq8]], [[6rq9]], [[6rqb]], [[6rqd]], [[6rqe]] - MtP450 CYP121 + dicyclo-Tyr derivative<br />
**[[6rq0]], [[6rq1]], [[6rq3]], [[6rq5]], [[6rq6]], [[6rq8]], [[6rq9]], [[6rqb]], [[6rqd]], [[6rqe]] - MtP450 CYP121 + dicyclo-Tyr derivative<br />
Line 143: Line 146:
**[[3iw1]] - MtP450 CYP125+androstenedione<br />
**[[3iw1]] - MtP450 CYP125+androstenedione<br />
**[[3iw2]] - MtP450 CYP125+econazole<br />
**[[3iw2]] - MtP450 CYP125+econazole<br />
 +
**[[7qke]], [[7qnn]], [[7qwn]], [[7r1i]], [[7r3u]], [[7yxf]], [[7zgl]], [[7zic]], [[7zlz]], [[7zqr]], [[7zsu]], [[7zt0]], [[7zxd]], [[8s4m]] - MtP450 CYP125 + inhibitor
**[[2uvn]] - MtP450 CYP130+econazole<br />
**[[2uvn]] - MtP450 CYP130+econazole<br />
**[[2wgy]] – MtP450 CYP130 (mutant)<br />
**[[2wgy]] – MtP450 CYP130 (mutant)<br />
**[[2w09]], [[2w0b]], [[2w0a]] - MtP450 CYP130 (mutant)+pyridine inhibitor<br />
**[[2w09]], [[2w0b]], [[2w0a]] - MtP450 CYP130 (mutant)+pyridine inhibitor<br />
**[[2uuq]] – MtP450 CYP130<br />
**[[2uuq]] – MtP450 CYP130<br />
 +
**[[8c9i]] - MtP450 CYP141A1<br />
 +
**[[8a9p]] - MtP450 CYP142A1<br />
 +
**[[7p5t]], [[7qq7]], [[8s53]] - MtP450 CYP142A1 + inhibitor<br />
 +
**[[8a6w]] - MtP450 CYP142A1 + choletenone<br />
 +
**[[8amo]], [[8ckn]] - MtP450 CYP143A1<br />
**[[5hdi]] - MtP450 CYP144A1<br />
**[[5hdi]] - MtP450 CYP144A1<br />
Line 237: Line 246:
*P450 BM3 or bifunctional P450/NADPH-P450 reductase; Domains – heme 1-458; FMN 459-647; FAD 659-1049
*P450 BM3 or bifunctional P450/NADPH-P450 reductase; Domains – heme 1-458; FMN 459-647; FAD 659-1049
-
**[[3cbd]], [[2bmh]], [[2j4s]], [[4zfa]], [[1bu7]] – BmP450 heme domain – ''Bacillus megaterium''<br />
+
**[[3cbd]], [[2bmh]], [[2j4s]], [[4zfa]], [[1bu7]], [[8q2f]] – PmP450 heme domain – ''Priestria megaterium''<br />
-
**[[3dgi]], [[3hf2]], [[3kx3]], [[3kx4]], [[3kx5]], [[3m4v]], [[3npl]], [[3psx]], [[4dty]], [[4dua]], [[4duc]], [[4dud]], [[1jme]], [[1p0v]], [[1p0w]], [[1p0x]], [[1smi]], [[1yqp]], [[1yqo]], [[1zo4]], [[2nnb]], [[4hgj]], [[4h23]], [[4h24]], [[4kpb]], [[4kf0]], [[4kf2]], [[4wg2]], [[1fah]], [[4rsn]], [[4zf6]], [[5dyp]], [[5e7y]], [[5e9z]], [[5jqu]], [[5jqv]], [[5ucw]] - BmP450 heme domain (mutant)<br />
+
**[[3dgi]], [[3hf2]], [[3kx3]], [[3kx4]], [[3kx5]], [[3m4v]], [[3npl]], [[3psx]], [[4dty]], [[4dua]], [[4duc]], [[4dud]], [[1jme]], [[1p0v]], [[1p0w]], [[1p0x]], [[1smi]], [[1yqp]], [[1yqo]], [[1zo4]], [[2nnb]], [[4hgj]], [[4h23]], [[4h24]], [[4kpb]], [[4kf0]], [[4kf2]], [[4wg2]], [[1fah]], [[4rsn]], [[4zf6]], [[5dyp]], [[5e7y]], [[5e9z]], [[5jqu]], [[5jqv]], [[5ucw]], [[8dsg]], [[8qze]], [[8qzf]] - PmP450 heme domain (mutant)<br />
-
**[[5zlh]], [[5zis]] - BmP450 heme domain + Mn-protoporphyrin<br />
+
**[[5zlh]], [[5zis]] - PmP450 heme domain + Mn-protoporphyrin<br />
-
**[[4dtw]], [[4due]], [[4duf]] - BmP450 heme domain (mutant) + serotonin<br />
+
**[[4dtw]], [[4due]], [[4duf]] - PmP450 heme domain (mutant) + serotonin<br />
-
**[[4dtz]], [[4du2]], [[4dub]] - BmP450 heme domain (mutant) + dopamine<br />
+
**[[4dtz]], [[4du2]], [[4dub]] - PmP450 heme domain (mutant) + dopamine<br />
-
**[[1jpz]], [[1zo9]], [[1zoa]], [[4kpa]] - BmP450 heme domain + palmitate derivative<br />
+
**[[1jpz]], [[1zo9]], [[1zoa]], [[4kpa]] - PmP450 heme domain + palmitate derivative<br />
-
**[[1smj]], [[5jq2]] - BmP450 heme domain (mutant) + palmitate derivative<br />
+
**[[1smj]], [[5jq2]] - PmP450 heme domain (mutant) + palmitate derivative<br />
-
**[[2x7y]], [[2x80]] - BmP450 heme domain (mutant) + DMSO<br />
+
**[[9iss]], [[9isu]] - PmP450 heme domain (mutant) + decanoyl homoserine<br />
-
**[[6iao]] - BmP450 heme domain (mutant) + DTT<br />
+
**[[2x7y]], [[2x80]] - PmP450 heme domain (mutant) + DMSO<br />
-
**[[4hgf]], [[4hgg]], [[4hgh]], [[4hgi]] - BmP450 heme domain (mutant) + styrene<br />
+
**[[6iao]] - PmP450 heme domain (mutant) + DTT<br />
-
**[[4kew]], [[4key]], [[4o4p]], [[4zf8]], [[6h1l]], [[6h1o]], [[6h1s]], [[6h1t]], [[6hn8]] - BmP450 heme domain (mutant) + drug<br />
+
**[[4hgf]], [[4hgg]], [[4hgh]], [[4hgi]] - PmP450 heme domain (mutant) + styrene<br />
-
**[[3ekb]], [[3ekd]], [[3ekf]], [[2ij3]], [[2ij4]] - BmP450102 heme domain (mutant)<br />
+
**[[4kew]], [[4key]], [[4o4p]], [[4zf8]], [[6h1l]], [[6h1o]], [[6h1s]], [[6h1t]], [[6hn8]] - PmP450 heme domain (mutant) + drug<br />
-
**[[2ij2]], [[2hpd]] - BmP450102 heme domain<br />
+
**[[3ekb]], [[3ekd]], [[3ekf]], [[2ij3]], [[2ij4]] - PmP450102 heme domain (mutant)<br />
-
**[[6jlv]], [[6jmh]], [[6jmw]], [[6js8]], [[6jvc]], [[6k24]], [[6k9s]] - BmP450102 heme domain + abietoyl-Trp<br />
+
**[[2ij2]], [[2hpd]], [[8dme]], [[8dmg]] - PmP450102 heme domain<br />
-
**[[6jzs]] - BmP450102 heme domain + abietoyl-Trp + pyridine<br />
+
**[[6jlv]], [[6jmh]], [[6jmw]], [[6js8]], [[6jvc]], [[6k24]], [[6k9s]] - PmP450102 heme domain + abietoyl-Trp<br />
-
**[[6k3q]], [[6k58]], [[6jo1]] - BmP450102 heme domain + Phe derivative<br />
+
**[[6jzs]] - PmP450102 heme domain + abietoyl-Trp + pyridine<br />
-
**[[4dqk]] - BmP450 FAD domain + FAD<br />
+
**[[6k3q]], [[6k58]], [[6jo1]], [[7wg0]], [[7xzk]] - PmP450102 heme domain + Phe derivative<br />
-
**[[4dql]] - BmP450 FAD domain + NADP + FAD<br />
+
**[[4dqk]] - PmP450 FAD domain + FAD<br />
-
**[[3wsp]] - BmP450 heme domain + decoy molecule<br />
+
**[[4dql]] - PmP450 FAD domain + NADP + FAD<br />
-
**[[2uwh]] - BmP450102+palmitic acid<br />
+
**[[3wsp]] - PmP450 heme domain + decoy molecule<br />
-
**[[3ben]], [[7egn]] - BmP450 heme domain + inhibitor<br />
+
**[[2uwh]] - PmP450102+palmitic acid<br />
-
**[[2j1m]] - BmP450102 heme domain +DMSO<br />
+
**[[3ben]], [[7egn]] - PmP450 heme domain + inhibitor<br />
-
**[[5jtd]] - BmP450102 heme domain (mutant) +DMSO<br />
+
**[[2j1m]] - PmP450102 heme domain +DMSO<br />
-
**[[1bvy]] – BmP450102A1 heme+FMN domains<br />
+
**[[5jtd]] - PmP450102 heme domain (mutant) +DMSO<br />
-
**[[5e78]] - BmP450 heme domain + Co + sepulchrate<br />
+
**[[1bvy]] – PmP450102A1 heme+FMN domains<br />
-
**[[1fag]] – BmP450102A1 heme domain + palmitate<br />
+
**[[5e78]] - PmP450 heme domain + Co + sepulchrate<br />
-
**[[4zfb]], [[5dyz]] - BmP450 (mutant) + palmitate<br />
+
**[[1fag]] – PmP450102A1 heme domain + palmitate<br />
-
**[[5b2v]], [[5b2y]], [[5xa3]], [[5xhj]] - BmP450 heme domain + amino acid derivative<br />
+
**[[4zfb]], [[5dyz]] - PmP450 (mutant) + palmitate<br />
-
**[[5og9]] - BmP450 heme domain + testosterone<br />
+
**[[5b2v]], [[5b2y]], [[5xa3]], [[5xhj]] - PmP450 heme domain + amino acid derivative<br />
-
**[[6ly4]] - BmP450 heme domain (mutant) + testosterone<br />
+
**[[5og9]] - PmP450 heme domain + testosterone<br />
-
**[[5b2u]], [[5b2w]], [[5b2x]] - BmP450 heme domain (mutant) + tryptophan derivative<br />
+
**[[6ly4]] - PmP450 heme domain (mutant) + testosterone<br />
-
**[[7ckn]], [[7con]], [[7coo]], [[7cp8]], [[7cx8]], [[7d0t]], [[7d0u]], [[7d1f]], [[7e46]], [[7w97]], [[7w9d]], [[7w9j]] - PmP450 heme domain CYP102A1 + inhibitor<br />
+
**[[5b2u]], [[5b2w]], [[5b2x]] - PmP450 heme domain (mutant) + tryptophan derivative<br />
-
**[[4yt3]] - BmP450 CYP106A2 <br />
+
**[[7y9k]], [[7y9m]] - PmP450 heme domain (mutant) <br />
-
**[[5iki]] - BmP450 CYP106A2 + abietic acid <br />
+
**[[7ckn]], [[7con]], [[7coo]], [[7cp8]], [[7cx8]], [[7d0t]], [[7d0u]], [[7d1f]], [[7e46]], [[7w97]], [[7w9d]], [[7w9j]] - PmP450 heme domain CYP102A1 + inhibitor <br />
-
**[[5l90]] - BmP450 CYP109E1 <br />
+
**[[7y9j]], [[7y9l]], [[7yde]] - PmP450 heme domain CYP102A1 (mutant) + inhibitor <br />
-
**[[5l91]], [[5l92]] - BmP450 CYP109E1 + corticosterone<br />
+
**[[8yay]], [[8yb0]], [[8yb1]], [[8yb2]] - PmP450 (mutant) + styrene <br />
-
**[[5l94]] - BmP450 CYP109E1 + testosterone<br />
+
**[[7y0q]] - PmP450 (mutant) + methylaniline <br />
 +
**[[7y0t]], [[7yd9]], [[7ydl]], [[7yje]], [[8hot]] - PmP450 (mutant) + Phe derivative<br />
 +
**[[7wy3]], [[7wy4]], [[8yaz]], [[8yb3]] - PmP450 (mutant) + styrene + Phe derivative<br />
 +
**[[7wdd]], [[7wde]], [[7wdg]], [[7wdh]], [[7wdi]], [[7y0r]], [[7y0u]], [[7yda]], [[7ydb]], [[7yft]], [[7yjg]], [[7yjh]] - PmP450 (mutant) + hydroxylamine + Phe derivative<br />
 +
**[[7y0s]] - PmP450 (mutant) + hydroxylamine + Tyr derivative<br />
 +
**[[7y0p]], [[7ydc]], [[7yjd]], [[8jc3]], [[8jc4]] - PmP450 (mutant) + hydroxylamine + Phe derivative<br />
 +
**[[7wy1]] - PmP450 + peptide <br />
 +
**[[7wy2]], [[8hon]], [[8hoo]], [[8hop]], [[8hoq]], [[8hor]], [[8hos]], [[8hou]] - PmP450 (mutant) + peptide <br />
 +
**[[9ist]] - PmP450 (mutant) + lactone<br />
 +
**[[8hkj]] - P450 CYP102A5 – ''Bacillus cereus''<br />
 +
**[[4yt3]] - PmP450 CYP106A2 <br />
 +
**[[5iki]] - PmP450 CYP106A2 + abietic acid <br />
 +
**[[8abs]] - PmP450 CYP109A2 + testosterone + octanoate <br />
 +
**[[8abr]] - PmP450 CYP109A2 + hexanoate + octanoate <br />
 +
**[[5l90]] - PmP450 CYP109E1 <br />
 +
**[[5l91]], [[5l92]] - PmP450 CYP109E1 + corticosterone<br />
 +
**[[5l94]] - PmP450 CYP109E1 + testosterone<br />
**[[7f3h]] - P450 heme domain – ''Deinococcus aerius''<br />
**[[7f3h]] - P450 heme domain – ''Deinococcus aerius''<br />
**[[7f3w]] - P450 heme domain – ''Deinococcus apachensis''<br />
**[[7f3w]] - P450 heme domain – ''Deinococcus apachensis''<br />
Line 308: Line 333:
**[[6ay4]], [[6ayb]], [[6ayc]] – NfP450 CYP51 + drug – ''Naegleria fowleri''<br />
**[[6ay4]], [[6ayb]], [[6ayc]] – NfP450 CYP51 + drug – ''Naegleria fowleri''<br />
**[[3l4d]] – P450 CYP51 + drug – ''Leishmania infantum''<br />
**[[3l4d]] – P450 CYP51 + drug – ''Leishmania infantum''<br />
 +
**[[5v5z]] – CaP450 CYP51 – ''Candida albicans''<br />
 +
**[[5tz1]] – CaP450 CYP51 + drug <br />
 +
**[[5fsa]] – CaP450 CYP51 (mutant) + drug <br />
 +
**[[3g1q]] – TbP450 CYP51 – ''Trypanosoma brucei''<br />
* Other CYPs
* Other CYPs
Line 325: Line 354:
**[[5gwe]], [[7ccf]] – CgP450 CreJ – ''Corynebacterium glutamicum''<br />
**[[5gwe]], [[7ccf]] – CgP450 CreJ – ''Corynebacterium glutamicum''<br />
**[[5y1i]] - P450 GFSF – ''Streptomyces graminofaciens''<br />
**[[5y1i]] - P450 GFSF – ''Streptomyces graminofaciens''<br />
 +
**[[8q6z]] - P450 GymB1 – ''Streptomyces flavidovirens''<br />
 +
**[[8q6x]] - SkP450 GymB5 – ''Streptomyces katrae''<br />
 +
**[[8spc]], [[8spp]] - P450 – ''Streptomyces atratus''<br />
**[[1cpt]] – PsP450 TERP - ''Pseudomonas sp.''<br />
**[[1cpt]] – PsP450 TERP - ''Pseudomonas sp.''<br />
**[[4l0e]], [[4l0f]] - StP450 SKY32– ''Streptomyces''<br />
**[[4l0e]], [[4l0f]] - StP450 SKY32– ''Streptomyces''<br />
 +
**[[6w0s]] - StP450-F5053<br />
 +
**[[8ho1]] - StP450-F5053 (mutant)<br />
 +
**[[8w72]] - StP450<br />
 +
**[[8fz8]] - P450 SKY2– ''Streptomyces nodosus''<br />
**[[3awp]], [[3awq]] - SpP450-α (mutant) - ''Sphingomonas paucimobilis''<br />
**[[3awp]], [[3awq]] - SpP450-α (mutant) - ''Sphingomonas paucimobilis''<br />
**[[3a4g]], [[3a4h]] – PaP450 VDH – ''Pseudonocardia autotrophica''<br />
**[[3a4g]], [[3a4h]] – PaP450 VDH – ''Pseudonocardia autotrophica''<br />
Line 343: Line 379:
**[[3e5j]], [[3e5l]] - SaP450 CYP105P1 (mutant)<br />
**[[3e5j]], [[3e5l]] - SaP450 CYP105P1 (mutant)<br />
**[[2z3u]] - SgP450 CYP105A1 (mutant) – ''Streptomyces griseolus''<br />
**[[2z3u]] - SgP450 CYP105A1 (mutant) – ''Streptomyces griseolus''<br />
 +
**[[8swl]] – MmP450 CYP105Q4<br />
**[[5xnt]] - P450 CYP106A2 – ''Bacillus butanolivorans''<br />
**[[5xnt]] - P450 CYP106A2 – ''Bacillus butanolivorans''<br />
**[[6l39]] - SrP450 CYP107G1 – ''Streptomyces rapamycinicus''<br />
**[[6l39]] - SrP450 CYP107G1 – ''Streptomyces rapamycinicus''<br />
**[[4wpz]] - SaP450 CYP107W1 <br />
**[[4wpz]] - SaP450 CYP107W1 <br />
-
**[[2whw]], [[2wi9]], [[2vz7]] – SvP450107L1 (mutant) – ''Streptomyces venezuelae''<br />
+
**[[7wex]] - SaP450 CYP107X1 <br />
 +
**[[2whw]], [[2wi9]], [[2vz7]], [[7xbn]] – SvP450107L1 (mutant) – ''Streptomyces venezuelae''<br />
**[[2bvj]] - SvP450107L1<br />
**[[2bvj]] - SvP450107L1<br />
**[[3tkt]] – NaP450 CYP108D1<br />
**[[3tkt]] – NaP450 CYP108D1<br />
**[[5ofq]] - BmP450 CYP109A2<br />
**[[5ofq]] - BmP450 CYP109A2<br />
**[[4rm4]] - BsP450 CYP109B1<br />
**[[4rm4]] - BsP450 CYP109B1<br />
 +
**[[7y97]], [[7y9o]] - BsP450 CYP109B4 – ''Bacillus sonorensis''<br />
**[[2jjn]], [[2jjo]] - SeP450 CYP113A1 (mutant) - ''Saccharopolyspora erythraea''<br />
**[[2jjn]], [[2jjo]] - SeP450 CYP113A1 (mutant) - ''Saccharopolyspora erythraea''<br />
 +
**[[8fib]] - EtP450 Cyp114 – ''Erwinia tracheiphila''<br />
 +
**[[8fie]] - EtP450 Cyp114 (mutant)<br />
**[[6ro8]] - P450 CYP116B5 – ''Acinetobacter radioresistens''<br />
**[[6ro8]] - P450 CYP116B5 – ''Acinetobacter radioresistens''<br />
**[[1io8]], [[5bv5]] – SsP450 CYP119 (mutant) – ''Sulfolobus solfataricus''<br />
**[[1io8]], [[5bv5]] – SsP450 CYP119 (mutant) – ''Sulfolobus solfataricus''<br />
**[[1io9]], [[1io7]], [[1f4u]] - SsP450 CYP119<br />
**[[1io9]], [[1io7]], [[1f4u]] - SsP450 CYP119<br />
-
**[[6cvc]] – MmP450 CYP124A1<br />
+
**[[6cvc]], [[8flo]] – MmP450 CYP124A1<br />
**[[5dqn]] - MsP450 CYP125A3 (mutant) – ''Mycobacterium smegmatis''<br />
**[[5dqn]] - MsP450 CYP125A3 (mutant) – ''Mycobacterium smegmatis''<br />
**[[3nc3]], [[3nc5]], [[3nc6]], [[3nc7]] - BsP450 CYP134A1 (mutant)<br />
**[[3nc3]], [[3nc5]], [[3nc6]], [[3nc7]] - BsP450 CYP134A1 (mutant)<br />
 +
**[[7pq1]], [[8a91]], [[8adr]], [[8ae8]] - SaP450 CYP134A1 – ''Staphylococcus aureus''<br />
**[[7tlo]] – MmP450 CYP142A3 <br />
**[[7tlo]] – MmP450 CYP142A3 <br />
**[[2zqj]] – BsP450152A1 – ''Bacillus subtilis''<br />
**[[2zqj]] – BsP450152A1 – ''Bacillus subtilis''<br />
**[[5fyf]] - MhP450 CYP153A – ''Marinobacter hydrocarbonoclasticus''<br />
**[[5fyf]] - MhP450 CYP153A – ''Marinobacter hydrocarbonoclasticus''<br />
 +
**[[8hgt]] - MnP450 CYP153A – ''Marinobacter nauticus''<br />
 +
**[[8hgd]] - MnP450 CYP153A (mutant)<br />
**[[6hqg]] - P450 CYP153 – ''Phenylobacterium zucineum''<br />
**[[6hqg]] - P450 CYP153 – ''Phenylobacterium zucineum''<br />
**[[6hqd]] – PsP450 CYP153 <br />
**[[6hqd]] – PsP450 CYP153 <br />
**[[7ant]] – PoP450 CYP153 - ''Polaromonas''<br />
**[[7ant]] – PoP450 CYP153 - ''Polaromonas''<br />
**[[1gwi]] - ScP450 CYP154C1<br />
**[[1gwi]] - ScP450 CYP154C1<br />
-
**[[6a7i]] - SvP450 CYP154C4 – Streptomyces violaceruber<br />
+
**[[6a7i]] - SvP450 CYP154C4 – ''Streptomyces violaceruber''<br />
**[[2nz5]], [[2nza]], [[2dkk]] – ScP450 CYP158A1 – ''Streptomyces coelicolor''<br />
**[[2nz5]], [[2nza]], [[2dkk]] – ScP450 CYP158A1 – ''Streptomyces coelicolor''<br />
**[[3r9b]] – MsP450 CYP164A2 <br />
**[[3r9b]] – MsP450 CYP164A2 <br />
Line 371: Line 415:
**[[3o1a]] – P450 CYP165D3 – ''Actinoplanes teichomyceticus''<br />
**[[3o1a]] – P450 CYP165D3 – ''Actinoplanes teichomyceticus''<br />
**[[1n97]] – TtP450 CYP175A1<br />
**[[1n97]] – TtP450 CYP175A1<br />
 +
**[[7wzl]] – SaP450 CYP184A1 <br />
**[[4dnz]] – RpP450 CYP199A4 – ''Rhodopseudomonas palustris''<br />
**[[4dnz]] – RpP450 CYP199A4 – ''Rhodopseudomonas palustris''<br />
**[[2z3t]] - StrP450 CYP245A1 <br />
**[[2z3t]] - StrP450 CYP245A1 <br />
Line 385: Line 430:
**[[7v40]] – RcP450 – ''Rhodococcus coprophilus''<br />
**[[7v40]] – RcP450 – ''Rhodococcus coprophilus''<br />
**[[6zhz]] - SanP450 – ''Streptomyces antibioticus''<br />
**[[6zhz]] - SanP450 – ''Streptomyces antibioticus''<br />
-
**[[7qan]] - P450 – ''Micromonospora maris"<br />
+
**[[7qan]], [[8u3n]] - MiP450 – ''Micromonospora maris''<br />
 +
**[[8ukz]] - MiP450 (mutant)<br />
*Other CYPs complexes
*Other CYPs complexes
Line 400: Line 446:
**[[6hqq]], [[6hqr]], [[6hqt]] – AoP450 (mutant) + syringol<br />
**[[6hqq]], [[6hqr]], [[6hqt]] – AoP450 (mutant) + syringol<br />
**[[4pwv]], [[4pxh]] - StP450 SKY32 + peptidyl carrier protein domain<br />
**[[4pwv]], [[4pxh]] - StP450 SKY32 + peptidyl carrier protein domain<br />
 +
**[[8twu]] - StP450 ASPB + peptide<br />
 +
**[[8joo]], [[8jua]] - StP450 ikaD + drug<br />
 +
**[[8jnc]], [[8jno]] - StP450 ikaD + substrate<br />
 +
**[[8hny]], [[8hnz]], [[8ho0]] - StP450-F5053 (mutant) + pyrazine derivative<br />
 +
**[[6vza]], [[6vzb]] - StP450-F5053 (mutant) + peptide<br />
**[[2zqx]] - BsP450 BS b +heptanoic acid<br />
**[[2zqx]] - BsP450 BS b +heptanoic acid<br />
-
**[[1izo]] – BsP450 BS beta+ palmitoleic acid<br />
+
**[[1izo]], [[7wyg]] – BsP450 BS beta+ fatty acid<br />
**[[3awm]] – SpP450-α + palmitic acid <br />
**[[3awm]] – SpP450-α + palmitic acid <br />
**[[3a50]], [[3a51]] - PaP450 VDH (mutant) + vitamin D3<br />
**[[3a50]], [[3a51]] - PaP450 VDH (mutant) + vitamin D3<br />
Line 421: Line 472:
**[[3e5k]] - SaP450 CYP105P1 (mutant)+4-phenylimidazole<br />
**[[3e5k]] - SaP450 CYP105P1 (mutant)+4-phenylimidazole<br />
**[[4oqr]] - AoP450 CYP105AS1 (mutant) + compactin<br />
**[[4oqr]] - AoP450 CYP105AS1 (mutant) + compactin<br />
-
**[[7q9e]] - PmP450 CYP106A1 – Priestia megaterium<br />
+
**[[7q9e]], [[7zzl]] - PmP450 CYP106A1 – Priestia megaterium<br />
**[[7cvr]], [[7cx6]], [[7czi]] - PmP450 CYP106A1 + inhibitor<br />
**[[7cvr]], [[7cx6]], [[7czi]] - PmP450 CYP106A1 + inhibitor<br />
**[[1jin]], [[1jip]] - SeP450 CYP107A1+ ketoconazole <br />
**[[1jin]], [[1jip]] - SeP450 CYP107A1+ ketoconazole <br />
Line 434: Line 485:
**[[2cd8]], [[2ca0]], [[2c6h]] – SvP450 CYP107L1+YC-17<br />
**[[2cd8]], [[2ca0]], [[2c6h]] – SvP450 CYP107L1+YC-17<br />
**[[4tt5]], [[4tuv]], [[4wpd]], [[4wqj]] - P450 CYP119+ imidazole derivative – ''Sulfolobus acidocaldarius''<br />
**[[4tt5]], [[4tuv]], [[4wpd]], [[4wqj]] - P450 CYP119+ imidazole derivative – ''Sulfolobus acidocaldarius''<br />
 +
**[[7uor]] - SuaP450 CYP119 (mutant) + Ir-mesoporphyrin<br />
 +
**[[8fjo]], [[8fkb]] – MmP450 CYP124A1 + farnesol<br />
 +
**[[8gdi]] – MmP450 CYP124A1 + ketocholesterol<br />
 +
**[[8a8l]], [[8aa7]] - SaP450 CYP134A1 + indole <br />
**[[7smz]] – MmP450 CYP142A3 + cholestenone<br />
**[[7smz]] – MmP450 CYP142A3 + cholestenone<br />
 +
**[[7sh5]] – P450 CYP142A3 + cholesterol derivative – ''Mycobacterium ulcerans''<br />
**[[5yhj]] - P450 CYP152N1 + myristic acid - ''Exiguobacterium''<br />
**[[5yhj]] - P450 CYP152N1 + myristic acid - ''Exiguobacterium''<br />
**[[5fyg]] - MhP450 CYP153A + dodecanoic acid<br />
**[[5fyg]] - MhP450 CYP153A + dodecanoic acid<br />
**[[7ao7]] – PoP450 CYP153 + octanol <br />
**[[7ao7]] – PoP450 CYP153 + octanol <br />
 +
**[[8rtv]] – P450 CYP154E1 + Phenylimidazole – ''Thermobofida fusca'' <br />
**[[6to2]] - NfP450 CYP154C4 + androstan derivative – ''Nocardia farcinica'' <br />
**[[6to2]] - NfP450 CYP154C4 + androstan derivative – ''Nocardia farcinica'' <br />
**[[4j6b]], [[4jbc]], [[4jbd]], [[4jbt]] - NfP450 CYP154C5 + hormone<br />
**[[4j6b]], [[4jbc]], [[4jbd]], [[4jbt]] - NfP450 CYP154C5 + hormone<br />
**[[6a7j]] - SvP450 CYP154C4 + testosterone <br />
**[[6a7j]] - SvP450 CYP154C4 + testosterone <br />
**[[3r9c]] – MsP450 CYP164A2 + econazole<br />
**[[3r9c]] – MsP450 CYP164A2 + econazole<br />
-
**[[4do1]], [[4egm]], [[6c3j]], [[6c3h]], [[6c2d]], [[5yqh]], [[5yqa]], [[5uvb]], [[5u6w]], [[5u6u]], [[5u6t]], [[5kt1]], [[5kdb]], [[6oow]], [[6pq6]], [[6pqd]], [[6pqs]], [[6pqw]], [[6prr]], [[6prs]], [[6u30]], [[6u31]], [[6u3k]], [[7jw5]], [[7jxb]], [[7kcs]], [[7n14]], [[7r8s]], [[7r8t]], [[7reh]] – RpP450 CYP199A4 + benzoate derivative<br />
+
**[[7wzm]] – SaP450 CYP184A1 + oleic acid<br />
-
**[[5kdz]], [[5kdy]], [[6oox]] , [[7n60]]– RpP450 CYP199A4 (mutant) + benzoate derivative<br />
+
**[[4do1]], [[4egm]], [[6c3j]], [[6c3h]], [[6c2d]], [[5yqh]], [[5yqa]], [[5uvb]], [[5u6w]], [[5u6u]], [[5u6t]], [[5kt1]], [[5kdb]], [[6oow]], [[6pq6]], [[6pqd]], [[6pqs]], [[6pqw]], [[6prr]], [[6prs]], [[6u30]], [[6u31]], [[6u3k]], [[6vjx]], [[7jw5]], [[7jxb]], [[7kcs]], [[7n14]], [[7r8s]], [[7r8t]], [[7reh]], [[7trt]], [[7tru]], [[7tzm]], [[7tzn]], [[7tzw]], [[7tzx]], [[7tzy]], [[7u00]], [[8d39]], [[8e5j]], [[8vf0]], [[8vf3]], [[[8vfp]], [8vfr]], [[8vkf]], [[8vl0]] – RpP450 CYP199A4 + benzoate derivative<br />
 +
**[[5kdz]], [[5kdy]], [[6oox]], [[6wzp]], [[7n60]], [[7tnd]], [[7tnf]], [[7tnu]], [[7tp5]], [[7tp6]], [[7tqm]], [[7udf]], [[8d1c]], [[8dyb]], [[8g35]], [[8gly]], [[8glz]], [[8gm1]], [[8gm2]], [[8hgb]], [[8hgc]], [[8taw]], [[8tay]], [[8tnk]], [[8ws4]] – RpP450 CYP199A4 (mutant) + benzoate derivative<br />
**[[4egn]] – RpP450 CYP199A4 + veratric acid<br />
**[[4egn]] – RpP450 CYP199A4 + veratric acid<br />
**[[4egp]] – RpP450 CYP199A4 + naphthoic acid<br />
**[[4egp]] – RpP450 CYP199A4 + naphthoic acid<br />
 +
**[[8g36]] – RpP450 CYP199A4 + terephthalic acid<br />
**[[6unn]] – RpP450 CYP199A4 + cinnamic acid derivative<br />
**[[6unn]] – RpP450 CYP199A4 + cinnamic acid derivative<br />
**[[4ego]] – RpP450 CYP199A4 + indole derivative<br />
**[[4ego]] – RpP450 CYP199A4 + indole derivative<br />
 +
**[[9g9q]], [[9g9r]], [[9g9s]] – P450 CYP199A + benzoate derivative – ''Rhodococcus jostii''<br />
**[[3a1l]] – StrP450 CYP245A1+dichlorochrompyrrolic acid <br />
**[[3a1l]] – StrP450 CYP245A1+dichlorochrompyrrolic acid <br />
**[[6f88]], [[6f8c]] - ScP450 CYP260A1 (mutant) + progesterone<br />
**[[6f88]], [[6f8c]] - ScP450 CYP260A1 (mutant) + progesterone<br />
Line 463: Line 523:
**[[6j83]] - SbP450 TleB + NMVT<br />
**[[6j83]] - SbP450 TleB + NMVT<br />
**[[7v41]], [[7v45]], [[7v46]] – RcP450 + toluene derivative<br />
**[[7v41]], [[7v45]], [[7v46]] – RcP450 + toluene derivative<br />
 +
**[[8u09]] - AtP450 – Amycolatopsis thermoflava<br />
 +
**[[8u19]], [[8u1i]] - AtP450 + syringol <br />
 +
**[[8fic]], [[8fid]] - EtP450 + kaurenoic acid <br />
 +
**[[8euh]], [[8euk]], [[8eul]] – PsP450 terp + terpineol<br />
 +
**[[8u2m]], [[9bw8]] – MiP450 + biarylitide<br />
 +
**[[8q6y]] - SkP450 GymB5 + hypoxanthine + Tyr-Tyr<br />
 +
**[[8hge]] - MnP450 CYP153A (mutant)+ decanoate<br />
 +
**[[7y98]] - BsP450 CYP109B4 + testosterone<br />
 +
**[[8hge]] - MnP450 CYP153A (mutant)+ decanoate<br />
 +
**[[6yco]], [[6yct]] - AmP450 (mutant) + vanillin<br />
 +
**[[6ycj]] - AmP450 (mutant) + guaiacol<br />
 +
**[[8jnp]] - StP450 CftA + antibiotic – ''Streptomyces torulosus''<br />
 +
**[[8jnq]] - StP450 CftA + substrate<br />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D Structures of Cytochrome P450

Updated on 24-March-2025

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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