8yym

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Current revision (21:38, 26 March 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8yym is ON HOLD until Paper Publication
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==Cryo-EM structure of cylindrical fiber of MyD88 TIR==
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<StructureSection load='8yym' size='340' side='right'caption='[[8yym]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8yym]] is a 104 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YYM FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yym OCA], [https://pdbe.org/8yym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yym RCSB], [https://www.ebi.ac.uk/pdbsum/8yym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yym ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN] Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:[https://omim.org/entry/612260 612260]; also known as recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.<ref>PMID:19506249</ref> <ref>PMID:18669862</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN] Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity).<ref>PMID:9013863</ref> <ref>PMID:15361868</ref> <ref>PMID:18292575</ref> <ref>PMID:19506249</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Imamura K]]
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[[Category: Kasai K]]
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[[Category: Kato T]]
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[[Category: Makino F]]
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[[Category: Miyata T]]
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[[Category: Namba K]]
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[[Category: Narita A]]
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[[Category: Onishi H]]
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[[Category: Tochio H]]

Current revision

Cryo-EM structure of cylindrical fiber of MyD88 TIR

PDB ID 8yym

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OCA

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