9b4y

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Current revision (21:39, 26 March 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9b4y is ON HOLD until Paper Publication
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==Cryo-EM structure of importin alpha-1/beta bound to TDP-43==
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<StructureSection load='9b4y' size='340' side='right'caption='[[9b4y]], [[Resolution|resolution]] 3.74&Aring;' scene=''>
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Authors: Ko, Y., Cingolani, G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9b4y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9B4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9B4Y FirstGlance]. <br>
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Description: Cryo-EM structure of importin alpha-1/beta bound to TDP-43
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.74&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9b4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9b4y OCA], [https://pdbe.org/9b4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9b4y RCSB], [https://www.ebi.ac.uk/pdbsum/9b4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9b4y ProSAT]</span></td></tr>
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[[Category: Cingolani, G]]
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</table>
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[[Category: Ko, Y]]
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== Function ==
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[https://www.uniprot.org/uniprot/IMB1_HUMAN IMB1_HUMAN] Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports PRKCI into the nucleus.<ref>PMID:9687515</ref> <ref>PMID:10228156</ref> <ref>PMID:11891849</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Cingolani G]]
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[[Category: Ko Y]]

Current revision

Cryo-EM structure of importin alpha-1/beta bound to TDP-43

PDB ID 9b4y

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