9dhp
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Resting state 1 of the GluA2-gamma2 complex== | |
| - | + | <StructureSection load='9dhp' size='340' side='right'caption='[[9dhp]], [[Resolution|resolution]] 4.18Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9dhp]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DHP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.18Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9dhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9dhp OCA], [https://pdbe.org/9dhp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9dhp RCSB], [https://www.ebi.ac.uk/pdbsum/9dhp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9dhp ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Carrillo | + | == Disease == |
| - | [[Category: Jayaraman | + | [https://www.uniprot.org/uniprot/CCG2_MOUSE CCG2_MOUSE] Note=Defects in Cacng2 cause the stargazer (stg) phenotype. Stg mice have spike-wave seizures characteristic of absence epilepsy, with accompanying defects in the cerebellum and inner ear. |
| - | [[Category: Kumar Mondal | + | == Function == |
| + | [https://www.uniprot.org/uniprot/CCG2_MOUSE CCG2_MOUSE] Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Carrillo E]] | ||
| + | [[Category: Jayaraman V]] | ||
| + | [[Category: Kumar Mondal A]] | ||
| + | [[Category: Twomey EC]] | ||
Current revision
Resting state 1 of the GluA2-gamma2 complex
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