2l11

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (22:25, 26 March 2025) (edit) (undo)
 
Line 1: Line 1:
==Solution NMR structure of the Cbx3 in complex with H3K9me3 peptide==
==Solution NMR structure of the Cbx3 in complex with H3K9me3 peptide==
-
<StructureSection load='2l11' size='340' side='right'caption='[[2l11]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+
<StructureSection load='2l11' size='340' side='right'caption='[[2l11]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2l11]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L11 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2l11]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L11 FirstGlance]. <br>
-
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CBX3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l11 OCA], [https://pdbe.org/2l11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l11 RCSB], [https://www.ebi.ac.uk/pdbsum/2l11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l11 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l11 OCA], [https://pdbe.org/2l11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l11 RCSB], [https://www.ebi.ac.uk/pdbsum/2l11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l11 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/CBX3_HUMAN CBX3_HUMAN]] Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
+
[https://www.uniprot.org/uniprot/CBX3_HUMAN CBX3_HUMAN] Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 15: Line 15:
<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l1/2l11_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l1/2l11_consurf.spt"</scriptWhenChecked>
-
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
Line 33: Line 33:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C]]
+
[[Category: Xenopus laevis]]
-
[[Category: Edwards, A]]
+
[[Category: Arrowsmith C]]
-
[[Category: Fares, C]]
+
[[Category: Edwards A]]
-
[[Category: Gutmanas, A]]
+
[[Category: Fares C]]
-
[[Category: Kaustov, L]]
+
[[Category: Gutmanas A]]
-
[[Category: Lemak, A]]
+
[[Category: Kaustov L]]
-
[[Category: Loppnau, P]]
+
[[Category: Lemak A]]
-
[[Category: Min, J]]
+
[[Category: Loppnau P]]
-
[[Category: Quang, H]]
+
[[Category: Min J]]
-
[[Category: Structural genomic]]
+
[[Category: Quang H]]
-
[[Category: Chromodomain]]
+
-
[[Category: Sgc]]
+
-
[[Category: Transcription regulator]]
+

Current revision

Solution NMR structure of the Cbx3 in complex with H3K9me3 peptide

PDB ID 2l11

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2l11"
Personal tools