3sgn

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Current revision (22:46, 26 March 2025) (edit) (undo)
 
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<StructureSection load='3sgn' size='340' side='right'caption='[[3sgn]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
<StructureSection load='3sgn' size='340' side='right'caption='[[3sgn]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3sgn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SGN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3sgn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SGN FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=A8E:(2S)-2-AMINO-4-BROMOPENT-4-ENOIC+ACID'>A8E</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.807&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3sgm|3sgm]], [[3sgo|3sgo]], [[3sgp|3sgp]], [[3sgr|3sgr]], [[3sgs|3sgs]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A8E:(2S)-2-AMINO-4-BROMOPENT-4-ENOIC+ACID'>A8E</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sgn OCA], [https://pdbe.org/3sgn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sgn RCSB], [https://www.ebi.ac.uk/pdbsum/3sgn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sgn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sgn OCA], [https://pdbe.org/3sgn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sgn RCSB], [https://www.ebi.ac.uk/pdbsum/3sgn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sgn ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
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[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN] May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cascio, D]]
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[[Category: Cascio D]]
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[[Category: Eisenberg, D]]
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[[Category: Eisenberg D]]
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[[Category: Laganowsky, A]]
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[[Category: Laganowsky A]]
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[[Category: Sawaya, M R]]
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[[Category: Sawaya MR]]
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[[Category: Amyloid]]
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[[Category: Amyloid oligomer]]
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[[Category: Beta cylindrin]]
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[[Category: Protein fibril]]
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Current revision

Bromoderivative-8 of amyloid-related segment of alphaB-crystallin residues 90-100

PDB ID 3sgn

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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