3ubu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (22:49, 26 March 2025) (edit) (undo)
 
Line 4: Line 4:
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ubu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinagkistrodon_acutus Deinagkistrodon acutus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UBU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UBU FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ubu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinagkistrodon_acutus Deinagkistrodon acutus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UBU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UBU FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91&#8491;</td></tr>
-
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ubu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ubu OCA], [https://pdbe.org/3ubu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ubu RCSB], [https://www.ebi.ac.uk/pdbsum/3ubu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ubu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ubu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ubu OCA], [https://pdbe.org/3ubu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ubu RCSB], [https://www.ebi.ac.uk/pdbsum/3ubu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ubu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/SLA1_DEIAC SLA1_DEIAC]] Agglucetin specifically causes platelet aggregation and surface exposure of integrin alpha-IIb/beta-3 with a GPIb-(GP1BA-) dependent manner in washed platelets. It binds to human platelets in a saturable manner, and its binding is specifically blocked by anti-GP Ib mAb. It regulates endothelial cell survival and promotes angiogenesis by activating integrin alpha-v/beta-3 signaling through FAK/phosphatidylinositol 3-kinase (PI3K)/Akt pathway.<ref>PMID:11686327</ref> <ref>PMID:18312855</ref> [[https://www.uniprot.org/uniprot/SLB2_DEIAC SLB2_DEIAC]] Agglucetin specifically causes platelet aggregation and surface exposure of integrin alpha-IIb/beta-3 with a GPIb-(GP1BA-) dependent manner in washed platelets. It binds to human platelets in a saturable manner, and its binding is specifically blocked by anti-GP Ib mAb. It regulates endothelial cell survival and promotes angiogenesis by activating integrin alpha-v/beta-3 signaling through FAK/phosphatidylinositol 3-kinase (PI3K)/Akt pathway.<ref>PMID:11686327</ref> <ref>PMID:18312855</ref>
+
[https://www.uniprot.org/uniprot/SLA1_DEIAC SLA1_DEIAC] Agglucetin specifically causes platelet aggregation and surface exposure of integrin alpha-IIb/beta-3 with a GPIb-(GP1BA-) dependent manner in washed platelets. It binds to human platelets in a saturable manner, and its binding is specifically blocked by anti-GP Ib mAb. It regulates endothelial cell survival and promotes angiogenesis by activating integrin alpha-v/beta-3 signaling through FAK/phosphatidylinositol 3-kinase (PI3K)/Akt pathway.<ref>PMID:11686327</ref> <ref>PMID:18312855</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 25: Line 25:
[[Category: Deinagkistrodon acutus]]
[[Category: Deinagkistrodon acutus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Chen, H]]
+
[[Category: Chen H]]
-
[[Category: Gao, Y]]
+
[[Category: Gao Y]]
-
[[Category: Ge, H]]
+
[[Category: Ge H]]
-
[[Category: Li, H]]
+
[[Category: Li H]]
-
[[Category: Liu, Y]]
+
[[Category: Liu Y]]
-
[[Category: Niu, L]]
+
[[Category: Niu L]]
-
[[Category: Teng, M]]
+
[[Category: Teng M]]
-
[[Category: Agkisacucetin]]
+
-
[[Category: C-type lectin-like]]
+
-
[[Category: Dimer]]
+
-
[[Category: Gpib binding]]
+
-
[[Category: Gpib inhibitor]]
+
-
[[Category: Platelet inhibiting]]
+
-
[[Category: Toxin]]
+

Current revision

Crystal structure of agkisacucetin, a GpIb-binding snaclec (snake C-type lectin) that inhibits platelet

PDB ID 3ubu

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ubu"
Personal tools