1vde

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[[Image:1vde.gif|left|200px]]
[[Image:1vde.gif|left|200px]]
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{{Structure
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|PDB= 1vde |SIZE=350|CAPTION= <scene name='initialview01'>1vde</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1vde", creates the "Structure Box" on the page.
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|SITE=
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] </span>
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{{STRUCTURE_1vde| PDB=1vde | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vde OCA], [http://www.ebi.ac.uk/pdbsum/1vde PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1vde RCSB]</span>
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'''PI-SCEI, A HOMING ENDONUCLEASE WITH PROTEIN SPLICING ACTIVITY'''
'''PI-SCEI, A HOMING ENDONUCLEASE WITH PROTEIN SPLICING ACTIVITY'''
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==Reference==
==Reference==
Crystal structure of PI-SceI, a homing endonuclease with protein splicing activity., Duan X, Gimble FS, Quiocho FA, Cell. 1997 May 16;89(4):555-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9160747 9160747]
Crystal structure of PI-SceI, a homing endonuclease with protein splicing activity., Duan X, Gimble FS, Quiocho FA, Cell. 1997 May 16;89(4):555-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9160747 9160747]
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[[Category: H(+)-transporting two-sector ATPase]]
 
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Duan, X.]]
[[Category: Duan, X.]]
[[Category: Quiocho, F A.]]
[[Category: Quiocho, F A.]]
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[[Category: homing endonuclease]]
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[[Category: Homing endonuclease]]
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[[Category: protein splicing]]
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[[Category: Protein splicing]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:24:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:22:52 2008''
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Revision as of 09:24, 3 May 2008

Image:1vde.gif

Template:STRUCTURE 1vde

PI-SCEI, A HOMING ENDONUCLEASE WITH PROTEIN SPLICING ACTIVITY


Overview

PI-Scel is a bifunctional yeast protein that propagates its mobile gene by catalyzing protein splicing and site-specific DNA double-strand cleavage. Here, we report the 2.4 A crystal structure of the PI-Scel protein. The structure is composed of two separate domains (I and II) with novel folds and different functions. Domain I, which is elongated and formed largely from seven beta sheets, harbors the N and C termini residues and two His residues that are implicated in protein splicing. Domain II, which is compact and is primarily composed of two similar alpha/beta motifs related by local two-fold symmetry, contains the putative nuclease active site with a cluster of two acidic residues and one basic residue commonly found in restriction endonucleases. This report presents prototypic structures of domains with single endonuclease and protein splicing active sites.

About this Structure

1VDE is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of PI-SceI, a homing endonuclease with protein splicing activity., Duan X, Gimble FS, Quiocho FA, Cell. 1997 May 16;89(4):555-64. PMID:9160747 Page seeded by OCA on Sat May 3 12:24:25 2008

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