User:Matthew Pereira/Sandbox 1
From Proteopedia
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=SARS-CoV-2 De Novo Designed Minibinders= | =SARS-CoV-2 De Novo Designed Minibinders= | ||
| - | <StructureSection load='7jzl' size='350' frame='true' side='right' caption='SARS-CoV-2 Spike Protein Bound to Minibinders (PDB 7jzl)' scene='10/1075220/Monomerwithminibinder/ | + | <StructureSection load='7jzl' size='350' frame='true' side='right' caption='SARS-CoV-2 Spike Protein Bound to Minibinders (PDB 7jzl)' scene='10/1075220/Monomerwithminibinder/4'> |
This is test text to fill space. | This is test text to fill space. | ||
==Introduction== | ==Introduction== | ||
[https://en.wikipedia.org/wiki/COVID-19 COVID-19] | [https://en.wikipedia.org/wiki/COVID-19 COVID-19] | ||
| - | The viral SARS-CoV-2 membrane is covered in [https://en.wikipedia.org/wiki/Coronavirus_spike_protein spike proteins]. These proteins are what enable the virus to enter our cells via interaction with membrane surface proteins called "angiotensin-converting enzyme 2" (ACE-2) receptors. SARS-CoV-2 spike proteins <scene name='10/1075220/Spikeboundtoace-2/ | + | The viral SARS-CoV-2 membrane is covered in [https://en.wikipedia.org/wiki/Coronavirus_spike_protein spike proteins]. These proteins are what enable the virus to enter our cells via interaction with membrane surface proteins called "angiotensin-converting enzyme 2" (ACE-2) receptors. SARS-CoV-2 spike proteins <scene name='10/1075220/Spikeboundtoace-2/2'>bind with these receptors</scene> to induce phagocytosis of the receptor-viral body complex. |
==Function== | ==Function== | ||
| - | The minibinder associates with the SARS-CoV-2 spike protein binding domain for ACE-2 before it reaches a host cell. <scene name='10/1075220/Spikeblockedbyminibinder/ | + | The minibinder associates with the SARS-CoV-2 spike protein binding domain for ACE-2 before it reaches a host cell. <scene name='10/1075220/Spikeblockedbyminibinder/2'>This prevents association with ACE-2.</scene> |
==Stability== | ==Stability== | ||
[[Image:minibinder_with_surface.png|400 px|left|thumb|Placeholder Image to be Replaced]] Structure sourced from original source paper Longxing et al.<ref name="Longxing">PMID:32907861</ref> | [[Image:minibinder_with_surface.png|400 px|left|thumb|Placeholder Image to be Replaced]] Structure sourced from original source paper Longxing et al.<ref name="Longxing">PMID:32907861</ref> | ||
Revision as of 19:53, 1 April 2025
SARS-CoV-2 De Novo Designed Minibinders
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References
- ↑ Cao L, Goreshnik I, Coventry B, Case JB, Miller L, Kozodoy L, Chen RE, Carter L, Walls AC, Park YJ, Strauch EM, Stewart L, Diamond MS, Veesler D, Baker D. De novo design of picomolar SARS-CoV-2 miniprotein inhibitors. Science. 2020 Oct 23;370(6515):426-431. PMID:32907861 doi:10.1126/science.abd9909
Student Contributors
Matt Pereira, Giavanna Yowel, and Shae Bailey
