8rgx
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of the Bacterial Proteasome Activator Bpa of Mycobacterium tuberculosis== | |
| - | + | <StructureSection load='8rgx' size='340' side='right'caption='[[8rgx]], [[Resolution|resolution]] 3.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8rgx]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RGX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RGX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rgx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rgx OCA], [https://pdbe.org/8rgx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rgx RCSB], [https://www.ebi.ac.uk/pdbsum/8rgx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rgx ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BPA_MYCTU BPA_MYCTU] Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction. Can inhibit degradation of Pup-tagged substrates in vitro by competing with Mpa for association with the proteasome.<ref>PMID:25469515</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
| + | [[Category: Afanasyev P]] | ||
| + | [[Category: Boehringer D]] | ||
| + | [[Category: Glockshuber R]] | ||
| + | [[Category: Weber-Ban E]] | ||
| + | [[Category: Zdanowicz R]] | ||
| + | [[Category: Von Rosen T]] | ||
Current revision
Cryo-EM structure of the Bacterial Proteasome Activator Bpa of Mycobacterium tuberculosis
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