8wk6

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Current revision (09:03, 2 April 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8wk6 is ON HOLD until Paper Publication
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==Human AGT1-rBAT complex in the apo-state==
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<StructureSection load='8wk6' size='340' side='right'caption='[[8wk6]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8wk6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WK6 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.64&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wk6 OCA], [https://pdbe.org/8wk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wk6 RCSB], [https://www.ebi.ac.uk/pdbsum/8wk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wk6 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SLC31_HUMAN SLC31_HUMAN] Cystinuria type A;2p21 microdeletion syndrome;Atypical hypotonia-cystinuria syndrome;Hypotonia-cystinuria syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Hypotonia-cystinuria syndrome is a contiguous gene syndrome caused by a homozygous deletion on chromosome 2p21 that disrupts the gene represented in this entry and PREPL (PubMed:16385448, PubMed:21686663). A homozygous 77.4-kb deletion that disrupts the gene represented in this entry, PREPL, and CAMKMT, causes atypical hypotonia-cystinuria syndrome, characterized by mild to moderate mental retardation and respiratory chain complex IV deficiency (PubMed:21686663).<ref>PMID:16385448</ref> <ref>PMID:21686663</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/SLC31_HUMAN SLC31_HUMAN] Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule.<ref>PMID:11318953</ref> <ref>PMID:7686906</ref> <ref>PMID:8486766</ref> <ref>PMID:8663184</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Dong J]]
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[[Category: Shi TH]]
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[[Category: Yan RH]]

Current revision

Human AGT1-rBAT complex in the apo-state

PDB ID 8wk6

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