8y6w

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Current revision (09:03, 2 April 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8y6w is ON HOLD until 2026-08-03
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==TUG-1375 and 4-CMTB-bound human FFA2 in complex with Gi==
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<StructureSection load='8y6w' size='340' side='right'caption='[[8y6w]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8y6w]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Y6W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Y6W FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.19&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9UJ:(2~{R},4~{R})-2-(2-chlorophenyl)-3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]carbonyl-1,3-thiazolidine-4-carboxylic+acid'>9UJ</scene>, <scene name='pdbligand=A1LYC:(2~{S})-2-(4-chlorophenyl)-3-methyl-~{N}-(1,3-thiazol-2-yl)butanamide'>A1LYC</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8y6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8y6w OCA], [https://pdbe.org/8y6w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8y6w RCSB], [https://www.ebi.ac.uk/pdbsum/8y6w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8y6w ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Fukuda M]]
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[[Category: Inoue A]]
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[[Category: Inoue W]]
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[[Category: Kato HE]]
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[[Category: Kawakami K]]
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[[Category: Kise R]]
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[[Category: Kobayashi K]]
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[[Category: Kojima A]]
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[[Category: Kugawa M]]

Current revision

TUG-1375 and 4-CMTB-bound human FFA2 in complex with Gi

PDB ID 8y6w

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OCA

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