8yt9

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Current revision (09:05, 2 April 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8yt9 is ON HOLD until Paper Publication
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==Human PPAR alpha ligand binding domain in complex with a 1H-pyrazolo[3,4-b]pyridine-derived compound==
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<StructureSection load='8yt9' size='340' side='right'caption='[[8yt9]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
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Authors: Tachibana, K., Morie, T., Fukuda, S., Yuzuriha, T., Ishimoto, K., Nunomura, K., Lin, B., Miyachi, H., Oki, H., Kawahara, K., Meguro, K., Nakagawa, S., Tsujikawa, K., Akai, S., Doi, T., Yoshida, T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8yt9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YT9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YT9 FirstGlance]. <br>
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Description: Human PPAR alpha ligand binding domain in complex with a 1H-pyrazolo[3,4-b]pyridine-derived compound
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1LZY:1-(4-fluorophenyl)-6-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-3-pentan-3-yl-pyrazolo[3,4-b]pyridine-4-carboxylic+acid'>A1LZY</scene></td></tr>
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[[Category: Tachibana, K]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yt9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yt9 OCA], [https://pdbe.org/8yt9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yt9 RCSB], [https://www.ebi.ac.uk/pdbsum/8yt9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yt9 ProSAT]</span></td></tr>
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[[Category: Yuzuriha, T]]
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</table>
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[[Category: Fukuda, S]]
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== Function ==
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[[Category: Yoshida, T]]
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[https://www.uniprot.org/uniprot/PPARA_HUMAN PPARA_HUMAN] Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.<ref>PMID:7684926</ref> <ref>PMID:7629123</ref> <ref>PMID:9556573</ref> <ref>PMID:10195690</ref>
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[[Category: Lin, B]]
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== References ==
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[[Category: Tsujikawa, K]]
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<references/>
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[[Category: Ishimoto, K]]
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__TOC__
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[[Category: Doi, T]]
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</StructureSection>
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[[Category: Kawahara, K]]
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[[Category: Homo sapiens]]
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[[Category: Nakagawa, S]]
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[[Category: Large Structures]]
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[[Category: Morie, T]]
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[[Category: Akai S]]
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[[Category: Miyachi, H]]
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[[Category: Doi T]]
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[[Category: Meguro, K]]
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[[Category: Fukuda S]]
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[[Category: Nunomura, K]]
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[[Category: Ishimoto K]]
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[[Category: Akai, S]]
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[[Category: Kawahara K]]
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[[Category: Oki, H]]
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[[Category: Lin B]]
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[[Category: Meguro K]]
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[[Category: Miyachi H]]
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[[Category: Morie T]]
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[[Category: Nakagawa S]]
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[[Category: Nunomura K]]
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[[Category: Oki H]]
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[[Category: Tachibana K]]
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[[Category: Tsujikawa K]]
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[[Category: Yoshida T]]
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[[Category: Yuzuriha T]]

Current revision

Human PPAR alpha ligand binding domain in complex with a 1H-pyrazolo[3,4-b]pyridine-derived compound

PDB ID 8yt9

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