9iz0

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Current revision (09:24, 2 April 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9iz0 is ON HOLD until Paper Publication
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==ATM/Tel1 bound to CHK2 peptide==
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<StructureSection load='9iz0' size='340' side='right'caption='[[9iz0]], [[Resolution|resolution]] 3.63&Aring;' scene=''>
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Authors: Wang, P.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9iz0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IZ0 FirstGlance]. <br>
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Description: ATM/Tel1 bound to CHK2 peptide
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.63&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene></td></tr>
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[[Category: Wang, P]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9iz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9iz0 OCA], [https://pdbe.org/9iz0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9iz0 RCSB], [https://www.ebi.ac.uk/pdbsum/9iz0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9iz0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ATM_SCHPO ATM_SCHPO] Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Undirectly involved in the phosphorylation of rad32 which is necessary for its telomere function. Required for the control of telomere length and genome stability.<ref>PMID:10430579</ref> <ref>PMID:12196391</ref> <ref>PMID:15226425</ref> <ref>PMID:9771717</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Schizosaccharomyces pombe 972h-]]
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[[Category: Wang P]]

Current revision

ATM/Tel1 bound to CHK2 peptide

PDB ID 9iz0

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OCA

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