9iz7

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Current revision (09:24, 2 April 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9iz7 is ON HOLD until Paper Publication
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==ATM/Tel1 in Basal state==
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<StructureSection load='9iz7' size='340' side='right'caption='[[9iz7]], [[Resolution|resolution]] 4.32&Aring;' scene=''>
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Authors: Wang, P.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9iz7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IZ7 FirstGlance]. <br>
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Description: ATM/Tel1 in Basal state
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.32&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9iz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9iz7 OCA], [https://pdbe.org/9iz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9iz7 RCSB], [https://www.ebi.ac.uk/pdbsum/9iz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9iz7 ProSAT]</span></td></tr>
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[[Category: Wang, P]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ATM_SCHPO ATM_SCHPO] Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Undirectly involved in the phosphorylation of rad32 which is necessary for its telomere function. Required for the control of telomere length and genome stability.<ref>PMID:10430579</ref> <ref>PMID:12196391</ref> <ref>PMID:15226425</ref> <ref>PMID:9771717</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Schizosaccharomyces pombe]]
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[[Category: Wang P]]

Current revision

ATM/Tel1 in Basal state

PDB ID 9iz7

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