6ed7

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Current revision (09:45, 2 April 2025) (edit) (undo)
 
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<StructureSection load='6ed7' size='340' side='right'caption='[[6ed7]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
<StructureSection load='6ed7' size='340' side='right'caption='[[6ed7]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ed7]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ED7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ED7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ed7]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ED7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ED7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=J4J:2-[(2-nitrophenyl)sulfanyl]acetohydrazide'>J4J</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.43&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bioA, EL75_3021, EL79_3111, EL80_3072 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=J4J:2-[(2-nitrophenyl)sulfanyl]acetohydrazide'>J4J</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylmethionine--8-amino-7-oxononanoate_transaminase Adenosylmethionine--8-amino-7-oxononanoate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.62 2.6.1.62] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ed7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ed7 OCA], [https://pdbe.org/6ed7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ed7 RCSB], [https://www.ebi.ac.uk/pdbsum/6ed7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ed7 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ed7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ed7 OCA], [http://pdbe.org/6ed7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ed7 RCSB], [http://www.ebi.ac.uk/pdbsum/6ed7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ed7 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A0A0A0GYM0_ECOLX A0A0A0GYM0_ECOLX]] Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor.[HAMAP-Rule:MF_00834]
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[https://www.uniprot.org/uniprot/BIOA_ECOLI BIOA_ECOLI] Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor.<ref>PMID:1092681</ref>
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==See Also==
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*[[Aminotransferase 3D structures|Aminotransferase 3D structures]]
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*[[7%2C8-diaminopelargonic acid synthase 3D structures|7%2C8-diaminopelargonic acid synthase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Adenosylmethionine--8-amino-7-oxononanoate transaminase]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Brown, C M]]
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[[Category: Brown CM]]
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[[Category: Brown, E D]]
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[[Category: Brown ED]]
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[[Category: Chan, J]]
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[[Category: Chan J]]
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[[Category: Junop, M S]]
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[[Category: Junop MS]]
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[[Category: Zlitni, S]]
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[[Category: Zlitni S]]
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[[Category: Antibiotic]]
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[[Category: Inhibitor adduct complex]]
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[[Category: Transferase-antibiotic complex]]
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Current revision

Crystal structure of 7,8-diaminopelargonic acid synthase bound to inhibitor MAC13772

PDB ID 6ed7

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