Dihydrofolate reductase 3D structures
From Proteopedia
(Difference between revisions)
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**[[3f8y]], [[3f8z]], [[3f91]], [[3eig]], [[1dlr]], [[1dls]] – hDHFR (mutant) <br /> | **[[3f8y]], [[3f8z]], [[3f91]], [[3eig]], [[1dlr]], [[1dls]] – hDHFR (mutant) <br /> | ||
**[[3ia5]] – MpDHFR – ''Mritella profunda''<br /> | **[[3ia5]] – MpDHFR – ''Mritella profunda''<br /> | ||
| - | **[[2kgk]], [[2qk8]] – BaDHFR – ''Bacillus anthracis''<br /> | + | **[[2kgk]], [[2qk8]], [[8ssx]] – BaDHFR – ''Bacillus anthracis''<br /> |
**[[3dfr]] – LcDHFR – ''Lactobacillus casei''<br /> | **[[3dfr]] – LcDHFR – ''Lactobacillus casei''<br /> | ||
**[[2w9t]] – SaDHFR S1 - ''Staphylococcus aureus''<br /> | **[[2w9t]] – SaDHFR S1 - ''Staphylococcus aureus''<br /> | ||
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**[[1ai9]] – CaDHFR - ''Candida albicans''<br /> | **[[1ai9]] – CaDHFR - ''Candida albicans''<br /> | ||
**[[1cz3]], [[1d1g]] – DHFR – ''Thermotoga maritima''<br /> | **[[1cz3]], [[1d1g]] – DHFR – ''Thermotoga maritima''<br /> | ||
| - | **[[3q1h]], [[5fda]] – YpDHFR – ''Yersinia pestis''<br /> | + | **[[3q1h]], [[5fda]], [[8szd]] – YpDHFR – ''Yersinia pestis''<br /> |
**[[2l28]] – DHFR – ''Lactobacillus casei'' - NMR<BR /> | **[[2l28]] – DHFR – ''Lactobacillus casei'' - NMR<BR /> | ||
**[[3vco]] – DHFR – ''Schistosoma mansoni''<br /> | **[[3vco]] – DHFR – ''Schistosoma mansoni''<br /> | ||
**[[8f09]] – DHFR – uncultured bacteria<br /> | **[[8f09]] – DHFR – uncultured bacteria<br /> | ||
**[[7rzo]] – SmDHFR – ''Stenotrophomonas maltophila''<br /> | **[[7rzo]] – SmDHFR – ''Stenotrophomonas maltophila''<br /> | ||
| + | **[[7zzx]] – CaDHFR - ''Candidozyma auris''<br /> | ||
*DHFR-Thymidine synthase (TS) complex | *DHFR-Thymidine synthase (TS) complex | ||
**[[6pfi]] - hDHFR-TS + NADPH + dUMP + pyrimidine derivative <br /> | **[[6pfi]] - hDHFR-TS + NADPH + dUMP + pyrimidine derivative <br /> | ||
| + | **[[8dae]] - DHFR-TS – ''Arabidopsis thaliana'' <br /> | ||
**[[3cl9]], [[2h2q]], [[3qfx]] – TcDHFR-TS - ''Trypanosoma cruzi''<br /> | **[[3cl9]], [[2h2q]], [[3qfx]] – TcDHFR-TS - ''Trypanosoma cruzi''<br /> | ||
**[[1qzf]] - ChTcDHFR-TS – ''Cryptosporidium hominis''<br /> | **[[1qzf]] - ChTcDHFR-TS – ''Cryptosporidium hominis''<br /> | ||
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**[[3hbb]] – TcDHFR-TS+MTX & TMTX <br /> | **[[3hbb]] – TcDHFR-TS+MTX & TMTX <br /> | ||
**[[3dg8]], [[1j3i]], [[3dga]], [[3qgt]], [[6a2k]], [[6a2m]], [[6a2o]], [[7ctz]], [[7f3y]], [[7f3z]] - PfDHFR-TS+NADPH +dUMP+inhibitor – ''Plasmodium falciparum''<br /> | **[[3dg8]], [[1j3i]], [[3dga]], [[3qgt]], [[6a2k]], [[6a2m]], [[6a2o]], [[7ctz]], [[7f3y]], [[7f3z]] - PfDHFR-TS+NADPH +dUMP+inhibitor – ''Plasmodium falciparum''<br /> | ||
| - | **[[1j3k]], [[1j3j]], [[3jsu]], [[6a2l]], [[6a2n]], [[6a2p]] - PfDHFR-TS (mutant)+NADPH+dUMP+ inhibitor<br /> | + | **[[1j3k]], [[1j3j]], [[3jsu]], [[6a2l]], [[6a2n]], [[6a2p]], [[8jfb]], [[8jfc]], [[8wgm]], [[8wgn]], [[8yq8]], [[8yq9]] - PfDHFR-TS (mutant)+NADPH+dUMP+ inhibitor<br /> |
**[[7ctw]], [[7cty]] - PfDHFR-TS +NADPH+ inhibitor<br /> | **[[7ctw]], [[7cty]] - PfDHFR-TS +NADPH+ inhibitor<br /> | ||
| - | **[[3qg2]], [[6leu]], [[6lev]], [[6lez]], [[6lh9]], [[6lhi]], [[6lhj]] - PfDHFR-TS (mutant)+NADPH + inhibitor<br /> | + | **[[3qg2]], [[6leu]], [[6lev]], [[6lez]], [[6lh9]], [[6lhi]], [[6lhj]], [[8jfd]] - PfDHFR-TS (mutant)+NADPH + inhibitor<br /> |
**[[3um8]], [[4dph]], [[6kot]] - PfDHFR-TS + NADPH + anti-malarial drug<br /> | **[[3um8]], [[4dph]], [[6kot]] - PfDHFR-TS + NADPH + anti-malarial drug<br /> | ||
**[[3um5]], [[3um6]], [[4dp3]], [[6kp2]], [[6kp7]], [[6kpr]] - PfDHFR-TS (mutant)+NADPH + dUMP + anti-malarial drug<br /> | **[[3um5]], [[3um6]], [[4dp3]], [[6kp2]], [[6kp7]], [[6kpr]] - PfDHFR-TS (mutant)+NADPH + dUMP + anti-malarial drug<br /> | ||
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**[[1rx5]], [[3och]], [[6cqa]], [[6nxz]], [[6ny0]], [[7f3b]], [[7mqp]], [[7reb]] - EcDHFR+ inhibitor<br /> | **[[1rx5]], [[3och]], [[6cqa]], [[6nxz]], [[6ny0]], [[7f3b]], [[7mqp]], [[7reb]] - EcDHFR+ inhibitor<br /> | ||
**[[7nae]] – EcDHFR + TMP<br /> | **[[7nae]] – EcDHFR + TMP<br /> | ||
| + | **[[9daq]], [[9dar]] – EcDHFR + cycloguanil<br /> | ||
| + | **[[9cum]] – EcDHFR (mutant) + congo red<br /> | ||
**[[4eig]], [[4eiz]] – EcDHFR + antibody fragment<br /> | **[[4eig]], [[4eiz]] – EcDHFR + antibody fragment<br /> | ||
**[[2cig]] – MtDHFR+isoniazid derivative – ''Mycobacterium tuberculosis''<br /> | **[[2cig]] – MtDHFR+isoniazid derivative – ''Mycobacterium tuberculosis''<br /> | ||
**[[4klx]] - MtDHFR + ADP<br /> | **[[4klx]] - MtDHFR + ADP<br /> | ||
| + | **[[6vs5]] - MtDHFR + pyrazole derivative<br /> | ||
| + | **[[8cop]], [[8cow]], [[8cox]] – MtDHFR+pyrimidine derivative | ||
**[[3tq8]] - CbDHFR + TMP – ''Coxiella burnetii''<br /> | **[[3tq8]] - CbDHFR + TMP – ''Coxiella burnetii''<br /> | ||
**[[3tq9]] – CbDHFR + MTX<br /> | **[[3tq9]] – CbDHFR + MTX<br /> | ||
**[[4qi9]], [[5hi6]] - YpDHFR + MTX <br /> | **[[4qi9]], [[5hi6]] - YpDHFR + MTX <br /> | ||
| + | **[[8sze]] - YpDHFR + TMP <br /> | ||
**[[7myl]] - KpDHFR + TMP <br /> | **[[7myl]] - KpDHFR + TMP <br /> | ||
| - | + | **[[7l9t]] - MsDHFR + pyrimidine derivative – ''Mycobacterium smegmatis''<br /> | |
| + | |||
*''Ternary complexes with pyrimidine derivative'' | *''Ternary complexes with pyrimidine derivative'' | ||
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**[[4h95]], [[4h96]], [[4h97]], [[4hoe]], [[4hof]] - CaDHFR + NADPH + pyrimidine derivative<br /> | **[[4h95]], [[4h96]], [[4h97]], [[4hoe]], [[4hof]] - CaDHFR + NADPH + pyrimidine derivative<br /> | ||
**[[4km0]] – MtDHFR + ADP + pyrimidine derivative<br /> | **[[4km0]] – MtDHFR + ADP + pyrimidine derivative<br /> | ||
| - | **[[5ja3]], [[5u26]], [[5u27]], [[5ujf]], [[6ddp]], [[6dds]], [[6ddw]], [[6nnc]], [[6nne]] – MtDHFR + NADP + pyrimidine derivative<br /> | + | **[[5ja3]], [[5scd]], [[5scm]], [[5scn]], [[5sco]], [[5scp]], [[5scq]], [[5scr]], [[5sct]], [[5scu]], [[5scv]], [[5scw]], [[5scx]], [[5scy]], [[5scz]], [[5sd0]], [[5sd1]], [[5sd2]], [[5sd3]], [[5sd4]], [[5sd5]], [[5sd6]], [[5sd7]], [[5sd8]], [[5sd9]], [[5sda]], 5sdb]], [[5u26]], [[5u27]], [[5ujf]], [[6ddp]], [[6dds]], [[6ddw]], [[6nnc]], [[6nne]], [[8coq]] – MtDHFR + NADP + pyrimidine derivative<br /> |
**[[3nza]] - PncDHFR+NADPH+ pyrimidine derivative<br /> | **[[3nza]] - PncDHFR+NADPH+ pyrimidine derivative<br /> | ||
**[[4m7v]] - EfDHFR +NADPH + pyrimidine derivative - ''Enterococcus faecalis'' <br /> | **[[4m7v]] - EfDHFR +NADPH + pyrimidine derivative - ''Enterococcus faecalis'' <br /> | ||
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**[[6cxm]] - MsDHFR +NADPH + pyrimidine derivative – ''Mycobacterium smegmatis''<br /> | **[[6cxm]] - MsDHFR +NADPH + pyrimidine derivative – ''Mycobacterium smegmatis''<br /> | ||
**[[7k6c]] – DHFR (mutant) + NADPH + pyrimidine derivative –'' Mycobacterioides abscessus''<br /> | **[[7k6c]] – DHFR (mutant) + NADPH + pyrimidine derivative –'' Mycobacterioides abscessus''<br /> | ||
| - | **[[6uwq]], [[6uww]], [[7k69]], [[7k6a]], [[7kac]], [[7ki8]], [[7ki9]], [[7km7]], [[7km8]], [[7ka9]]] – MuDHFR + NADPH + pyrimidine derivative – | + | **[[6uwq]], [[6uww]], [[7k69]], [[7k6a]], [[7kac]], [[7ki8]], [[7ki9]], [[7km7]], [[7km8]], [[7ka9]], [[8cq8]], [[8cq9]], [[8cqa]] – MuDHFR + NADPH + pyrimidine derivative – Mycobacterium ulcerans<br /> |
| - | **[[7k68]], [[7k6a]] – MuDHFR (mutant) + NADPH + pyrimidine derivative <br /> | + | **[[7k68]], [[7k6a]], [[8f80]], [[8f81]], [[8f82]], [[8f83]], [[8f84]], [[8f85]], [[8ta0]], [[8ta1]], [[8tbr]] – MuDHFR (mutant) + NADPH + pyrimidine derivative <br /> |
**[[7rgo]] – EcDHFR + NADPH + pyrimidine derivative <br /> | **[[7rgo]] – EcDHFR + NADPH + pyrimidine derivative <br /> | ||
**[[7tj3]] – SmDHFR + NADPH + pyrimidine derivative <br /> | **[[7tj3]] – SmDHFR + NADPH + pyrimidine derivative <br /> | ||
| + | **[[8a0z]] – CaDHFR + NADPH + pyrimidine derivative <br /> | ||
| + | **[[8crh]] – CaDHFR + NADPH + cycloguanil<br /> | ||
*''Ternary complexes with quinazoline derivative'' | *''Ternary complexes with quinazoline derivative'' | ||
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**[[3fre]], [[2w9s]], [[3frb]] – SaDHFR (mutant)+TMP+NADPH<BR /> | **[[3fre]], [[2w9s]], [[3frb]] – SaDHFR (mutant)+TMP+NADPH<BR /> | ||
**[[4g8z]] - DHFR (mutant)+TMP+NADPH – ''Pneumocystis jirovecii''<br /> | **[[4g8z]] - DHFR (mutant)+TMP+NADPH – ''Pneumocystis jirovecii''<br /> | ||
| - | **[[2w3v]] – MaDHFR +TMP+NADPH – ''Mycobacterium avium''<br /> | + | **[[2w3v]], [[8vtc]] – MaDHFR +TMP+NADPH – ''Mycobacterium avium''<br /> |
**[[3jw3]], [[3jw5]] – BaDHFR (mutant)+ TMP +NADPH<BR /> | **[[3jw3]], [[3jw5]] – BaDHFR (mutant)+ TMP +NADPH<BR /> | ||
**[[3s9u]], [[3sa1]], [[3sa2]], [[3sai]] – BaDHFR (mutant) +TMP analog + NADP<br /> | **[[3s9u]], [[3sa1]], [[3sa2]], [[3sai]] – BaDHFR (mutant) +TMP analog + NADP<br /> | ||
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**[[1dg5]] - MtDHFR + TMP +NADPH<BR /> | **[[1dg5]] - MtDHFR + TMP +NADPH<BR /> | ||
**[[4km2]] - MtDHFR + ADP + TMP<br /> | **[[4km2]] - MtDHFR + ADP + TMP<br /> | ||
| - | **[[6xg4]], [[6xg5]], [[7mym]], [[7r6g]] - EcDHFR+NADPH+ TMP<br /> | + | **[[6xg4]], [[6xg5]], [[7mym]], [[7r6g]], [[9kz4]] - EcDHFR+NADPH+ TMP<br /> |
*''Ternary complexes with MTX'' | *''Ternary complexes with MTX'' | ||
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**[[3fyw]] – SaDHFR + AR-101+NADPH<BR /> | **[[3fyw]] – SaDHFR + AR-101+NADPH<BR /> | ||
**[[3frf]] – SaDHFR (mutant)+iclaprim+NADPH<BR /> | **[[3frf]] – SaDHFR (mutant)+iclaprim+NADPH<BR /> | ||
| + | **[[6pr6]], [[6pr7]], [[6pr8]], [[6pr9]], [[6prb]], [[6prd]] – SaDHFR + phthalazine derivative +NADPH<BR /> | ||
**[[2ano]], [[2anq]] - EcDHFR+NADPH+MS-SH08-17<br /> | **[[2ano]], [[2anq]] - EcDHFR+NADPH+MS-SH08-17<br /> | ||
**[[5uih]] - EcDHFR+NADP + drug<br /> | **[[5uih]] - EcDHFR+NADP + drug<br /> | ||
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**[[4kne]] - MtDHFR + ADP + anti-folate drug<br /> | **[[4kne]] - MtDHFR + ADP + anti-folate drug<br /> | ||
**[[1dg7]] - MtDHFR + 4-Br-WR99210 +NADPH<BR /> | **[[1dg7]] - MtDHFR + 4-Br-WR99210 +NADPH<BR /> | ||
| - | **[[6vs6]], [[6vs8]], [[6vs9]], [[6vsb]], [[6vsd]], [[6vse]], [[6vsf]], [[6vsg]] - MtDHFR + inhibitor +NADPH<BR /> | + | **[[6vs6]], [[6vs8]], [[6vs9]], [[6vsb]], [[6vsd]], [[6vse]], [[6vsf]], [[6vsg]], [[6vv6]], [[6vv7]], [[6vv9]], [[6vvb]] - MtDHFR + inhibitor +NADPH<BR /> |
| + | **[[8rht]] - DHFR + inhibitor + NADPH – ''Trypanosoma brucei''<BR /> | ||
*DHFR higher complexes | *DHFR higher complexes | ||
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**[[5uio]] - EcDHFR + pyrimidine diamine +NADPH + monophosphateadenosine diphosphoribose + aminobenzyl carbonyl glutamate<br /> | **[[5uio]] - EcDHFR + pyrimidine diamine +NADPH + monophosphateadenosine diphosphoribose + aminobenzyl carbonyl glutamate<br /> | ||
**[[5uip]] - EcDHFR (mutant) + pyrimidine diamine +NADPH + monophosphateadenosine diphosphoribose + aminobenzyl carbonyl glutamate<br /> | **[[5uip]] - EcDHFR (mutant) + pyrimidine diamine +NADPH + monophosphateadenosine diphosphoribose + aminobenzyl carbonyl glutamate<br /> | ||
| + | **[[8v9r]], [[9c87]] - EcDHFR + ClpXP + ADP + ATP + MTX – Cryo EM | ||
*DHFR+ligands | *DHFR+ligands | ||
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**[[1e26]] - PcDHFR-TS+NADP+folate<br /> | **[[1e26]] - PcDHFR-TS+NADP+folate<br /> | ||
**[[2jyb]] – HvDHFR+folate<br /> | **[[2jyb]] – HvDHFR+folate<br /> | ||
| + | **[[8e4f]] - DHFR+folate+ NADPH – ''Wuhereria bancrofti''<br /> | ||
| + | **[[8ucx]] – EcDHFR + folate <br /> | ||
**[[2rk1]] – EcDHFR+NADP+dihydrofolate<br /> | **[[2rk1]] – EcDHFR+NADP+dihydrofolate<br /> | ||
**[[7dfr]] - EcDHFR+NAP+NADP+folate<br /> | **[[7dfr]] - EcDHFR+NAP+NADP+folate<br /> | ||
**[[1ra8]], [[1rx8]], [[1rx4]] – EcDHFR+folate+ ADP derivative<br /> | **[[1ra8]], [[1rx8]], [[1rx4]] – EcDHFR+folate+ ADP derivative<br /> | ||
| - | **[[1rb2]], [[1rx2]], [[1ra2]], [[3ql3]], [[4kjj]], [[4kjk]], [[4nx6]], [[4nx7]], [[4pss]], [[4pst]], [[4psy]], [[4pth]], [[4ptj]], [[4rgc]], [[4x5f]], [[4x5g]], [[4x5h]], [[4x5i]], [[4x5j]], [[ | + | **[[1dyl]], [[1rb2]], [[1rx2]], [[1ra2]], [[3ql3]], [[4kjj]], [[4kjk]], [[4nx6]], [[4nx7]], [[4pss]], [[4pst]], [[4psy]], [[4pth]], [[4ptj]], [[4rgc]], [[4x5f]], [[4x5g]], [[4x5h]], [[4x5i]], [[4x5j]], [[5sss]], [[5sst]], [[5ssu]], [[5ssv]], [[[5ssw]], [7d3z]], [[7d49]], [[7d4l]], [[7d4x]], [[7d6g]], [[7fpl]], [[7fpm]], [[7fpn]], [[7fpo]], [[7fpp]], [[7fpq]], [[7fpr]], [[7fps]], [[7fpt]], [[7fpu]], [[7fpv]], [[7fpw]], [[7fpx]], [[7fpy]], [[7fpz]], [[7fq0]], [[7fq1]], [[7fq2]], [[7fq3]], [[7fq4]], [[7fq5]], [[7fq6]], [[7fq7]], [[7fq8]], [[7fq9]], [[7fqa]], [[7fqb]], [[7fqc]], [[7fqd]], [[7fqe]], [[7fqf]], [[7fqg]], [[7lvc]], [[8g50]], [[8uw0]] - EcDHFR+folate+NADP |
**[[4pdj]] - EcDHFR+folate+NADP – Neutron<br /> | **[[4pdj]] - EcDHFR+folate+NADP – Neutron<br /> | ||
| - | **[[ | + | **[[8g4z]] - EcDHFR+folate+NADP – Laue<br /> |
| + | **[[1dyh]], [[1dyj]], [[1rc4]], [[1rx6]], [[5cc9]], [[5ccc]], [[6cyv]], [[8dai]] - EcDHFR+folate derivative +NADP <br /> | ||
**[[3ql0]], [[4kjl]], [[4qle]], [[4qlf]], [[4qlg]] – EcDHFR (mutant) +folate+NADP<br /> | **[[3ql0]], [[4kjl]], [[4qle]], [[4qlf]], [[4qlg]] – EcDHFR (mutant) +folate+NADP<br /> | ||
**[[1rx7]], [[1rd7]], [[1re7]], [[5e8q]], [[5eaj]],[[1dyi]], [[1rf7]], [[6cw7]], [[6cxk]], [[1jol]], [[1jom]], [[6mr9]] - EcDHFR+folate derivative<br /> | **[[1rx7]], [[1rd7]], [[1re7]], [[5e8q]], [[5eaj]],[[1dyi]], [[1rf7]], [[6cw7]], [[6cxk]], [[1jol]], [[1jom]], [[6mr9]] - EcDHFR+folate derivative<br /> | ||
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**[[1cd2]] - PcHDFR+folate+NADPH<BR /> | **[[1cd2]] - PcHDFR+folate+NADPH<BR /> | ||
**[[2zza]] – MpDHFR+ folate +NADP<br /> | **[[2zza]] – MpDHFR+ folate +NADP<br /> | ||
| + | **[[8uvz]] - DHFR+ folate +NADP – ''Bacillus subtilis'' | ||
**[[3tqb]] – CbDHFR + NADPH + folate<br /> | **[[3tqb]] – CbDHFR + NADPH + folate<br /> | ||
**[[3frd]] – SaDHFR (mutant)+folate +NADP<br /> | **[[3frd]] – SaDHFR (mutant)+folate +NADP<br /> | ||
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**[[2rk2]], [[2p4t]], [[1ra9]], [[1rx9]] – EcDHFR+NADP<br /> | **[[2rk2]], [[2p4t]], [[1ra9]], [[1rx9]] – EcDHFR+NADP<br /> | ||
**[[1rx1]], [[1ra1]] - EcDHFR+NADPH<BR /> | **[[1rx1]], [[1ra1]] - EcDHFR+NADPH<BR /> | ||
| - | **[[5w3q]] - EcDHFR (mutant) +NADPH <br /> | + | **[[5w3q]], [[8vz4]] - EcDHFR (mutant) +NADPH <br /> |
**[[6dfr]] - EcDHFR+NAP+NADP<br /> | **[[6dfr]] - EcDHFR+NAP+NADP<br /> | ||
**[[1dg8]], [[4kl9]] - MtDHFR +NADPH<BR /> | **[[1dg8]], [[4kl9]] - MtDHFR +NADPH<BR /> | ||
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**[[4q67]], [[6pra]] - SaDHFR +NADPH <br /> | **[[4q67]], [[6pra]] - SaDHFR +NADPH <br /> | ||
**[[4q6a]] - SaDHFR (mutant) +NADPH <br /> | **[[4q6a]] - SaDHFR (mutant) +NADPH <br /> | ||
| - | + | **[[8a0n]] – CaDHFR + NADPH <br /> | |
**[[3k74]], [[4i13]], [[4i1n]] – EcDHFR+nanobody<br /> | **[[3k74]], [[4i13]], [[4i1n]] – EcDHFR+nanobody<br /> | ||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
3D Structures of Dihydrofolate reductase
Updated on 03-April-2025
