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Sandbox Reserved 1846
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'''Ashley Callaghan/Sandbox1''' | '''Ashley Callaghan/Sandbox1''' | ||
==Introduction== | ==Introduction== | ||
| - | Leaf branch compost [https://en.wikipedia.org/wiki/Cutinase cutinase] (LCC) is a versatile enzyme that is capable of breaking down both natural plant polymers and synthetic plastics.<ref name="Tournier">PMID:32269349</ref> It was discovered in a [https://en.wikipedia.org/wiki/Compost compost] heap, and it originally evolved to degrade cutin, the protective biopolymer in plant surfaces. LCC has also shown high efficiency in hydrolyzing [https://en.wikipedia.org/wiki/Polyethylene_terephthalate polyethylene terephthalate]. | + | Leaf branch compost [https://en.wikipedia.org/wiki/Cutinase cutinase] (LCC) is a versatile enzyme that is capable of breaking down both natural plant polymers and synthetic plastics.<ref name="Tournier">PMID:32269349</ref> It was discovered in a [https://en.wikipedia.org/wiki/Compost compost] heap, and it originally evolved to degrade cutin, the protective biopolymer in plant surfaces. LCC has also shown high efficiency in hydrolyzing [https://en.wikipedia.org/wiki/Polyethylene_terephthalate polyethylene terephthalate] (PET), which is a widely used plastic that contributes to global pollution. Unlike many other PET-degrading enzymes, LCC is both thermostable and has a high catalytic efficiency, which means it can function at temperatures that are optimal for industrial recycling processes. By breaking PET into its monomers, LCC enables the closed-loop recycling of plastic waste and reduces environmental accumulation. Research is focused on engineering LCC variants with improved activity and thermostability to accelerate plastic degradation. |
<ref name="Kolattukudy">PMID:17779010</ref> | <ref name="Kolattukudy">PMID:17779010</ref> | ||
<ref name="Burgin">PMID:38538850</ref> | <ref name="Burgin">PMID:38538850</ref> | ||
Revision as of 00:05, 4 April 2025
| This Sandbox is Reserved from March 18 through September 1, 2025 for use in the course CH462 Biochemistry II taught by R. Jeremy Johnson and Mark Macbeth at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1828 through Sandbox Reserved 1846. |
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Leaf Branch Compost Cutinase
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References
- ↑ Tournier V, Topham CM, Gilles A, David B, Folgoas C, Moya-Leclair E, Kamionka E, Desrousseaux ML, Texier H, Gavalda S, Cot M, Guemard E, Dalibey M, Nomme J, Cioci G, Barbe S, Chateau M, Andre I, Duquesne S, Marty A. An engineered PET depolymerase to break down and recycle plastic bottles. Nature. 2020 Apr;580(7802):216-219. doi: 10.1038/s41586-020-2149-4. Epub 2020 Apr, 8. PMID:32269349 doi:http://dx.doi.org/10.1038/s41586-020-2149-4
- ↑ Kolattukudy PE. Biopolyester membranes of plants: cutin and suberin. Science. 1980 May 30;208(4447):990-1000. PMID:17779010 doi:10.1126/science.208.4447.990
- ↑ Burgin T, Pollard BC, Knott BC, Mayes HB, Crowley MF, McGeehan JE, Beckham GT, Woodcock HL. The reaction mechanism of the Ideonella sakaiensis PETase enzyme. Commun Chem. 2024 Mar 27;7(1):65. PMID:38538850 doi:10.1038/s42004-024-01154-x
- ↑ Munhoz DR, Meng K, Wang L, Lwanga EH, Geissen V, Harkes P. Exploring the potential of earthworm gut bacteria for plastic degradation. Sci Total Environ. 2024 Jun 1;927:172175. PMID:38575018 doi:10.1016/j.scitotenv.2024.172175
Student Contributors
Ashley Callaghan Rebecca Hoff Simone McCowan
