5xen

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Current revision (08:53, 9 April 2025) (edit) (undo)
 
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<StructureSection load='5xen' size='340' side='right'caption='[[5xen]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
<StructureSection load='5xen' size='340' side='right'caption='[[5xen]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5xen]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XEN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XEN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5xen]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusobacterium_nucleatum_subsp._nucleatum_ATCC_25586 Fusobacterium nucleatum subsp. nucleatum ATCC 25586]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XEN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5xem|5xem]], [[5xeo|5xeo]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cysteine_synthase Cysteine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.47 2.5.1.47] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xen OCA], [https://pdbe.org/5xen PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xen RCSB], [https://www.ebi.ac.uk/pdbsum/5xen PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xen ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xen OCA], [http://pdbe.org/5xen PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xen RCSB], [http://www.ebi.ac.uk/pdbsum/5xen PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xen ProSAT]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q8RE94_FUSNN Q8RE94_FUSNN]
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Hydrogen sulfide produced by oral bacteria is responsible for oral malodour. Two homologous hydrogen sulfide-producing enzymes, Fn1220 and Cdl, from Fusobacterium nucleatum (which actively produces hydrogen sulfide) were overproduced, purified and crystallized. X-ray diffraction data were collected from the crystals using a synchrotron-radiation source. The Fn1220 crystal belonged to tetragonal space group P4(1)2(1)2 or P4(3)2(1)2 (unit-cell parameters a=b=116.8, c=99.2 A) and the Cdl crystal belonged to monoclinic space group P2(1) (unit-cell parameters a=84.9, b=70.9, c=87.6 A, beta=90.3 degrees ).
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Purification, crystallization and preliminary X-ray analysis of two hydrogen sulfide-producing enzymes from Fusobacterium nucleatum.,Kezuka Y, Abe N, Yoshida Y, Nonaka T Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Dec 1;68(Pt 12):1507-10., doi: 10.1107/S1744309112042546. Epub 2012 Nov 14. PMID:23192034<ref>PMID:23192034</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5xen" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cysteine synthase]]
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[[Category: Fusobacterium nucleatum subsp. nucleatum ATCC 25586]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kezuka, Y]]
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[[Category: Kezuka Y]]
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[[Category: Nonaka, T]]
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[[Category: Nonaka T]]
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[[Category: Yoshida, Y]]
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[[Category: Yoshida Y]]
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[[Category: Beta-replacement reaction]]
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[[Category: Hydrogen sulfide]]
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[[Category: L-cysteine]]
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[[Category: Lanthionine]]
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[[Category: Periodontal disease]]
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[[Category: Pyridoxal 5'-phosphate dependent enzyme]]
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[[Category: Transferase]]
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Current revision

Crystal structure of a hydrogen sulfide-producing enzyme (Fn1220) from Fusobacterium nucleatum in complex with L-serine-PLP Schiff base

PDB ID 5xen

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