6yl3

<table><tr><td colspan='2'>[[6yl3]] is a 36 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_enterocolitica_w22703 Yersinia enterocolitica w22703]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YL3 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YL3 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Urease Urease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.5 3.5.1.5] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yl3 OCA], [http://pdbe.org/6yl3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yl3 RCSB], [http://www.ebi.ac.uk/pdbsum/6yl3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yl3 ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Urease converts urea into ammonia and carbon dioxide and makes urea available as a nitrogen source for all forms of life except animals. In human bacterial pathogens, ureases also aid in the invasion of acidic environments such as the stomach by raising the surrounding pH. Here, we report the structure of urease from the pathogen Yersinia enterocolitica at 2 A resolution from cryo-electron microscopy. Y. enterocolitica urease is a dodecameric assembly of a trimer of three protein chains, ureA, ureB and ureC. The high data quality enables detailed visualization of the urease bimetal active site and of the impact of radiation damage. The obtained structure is of sufficient quality to support drug development efforts.

 

== References ==

[[Category: Adaixo, R]]

[[Category: Anton, L]]

[[Category: Jakob, R]]

[[Category: Mahi, M A]]

[[Category: Maier, T]]

[[Category: Righetto, R D]]

[[Category: Ringler, P]]

[[Category: Schwede, T]]

[[Category: Stahlberg, H]]

[[Category: Zivanov, J]]

[[Category: Pathogen]]