7blo

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Current revision (09:26, 9 April 2025) (edit) (undo)
 
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==VPS26 dimer region of metazoan membrane-assembled retromer:SNX3 complex modelled with human proteins==
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<StructureSection load='7blo' size='340' side='right'caption='[[7blo]]' scene=''>
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<StructureSection load='7blo' size='340' side='right'caption='[[7blo]], [[Resolution|resolution]] 9.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7blo]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BLO FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7blo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7blo OCA], [https://pdbe.org/7blo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7blo RCSB], [https://www.ebi.ac.uk/pdbsum/7blo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7blo ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PIB:2-(BUTANOYLOXY)-1-{[(HYDROXY{[2,3,4,6-TETRAHYDROXY-5-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL)OXY]METHYL}ETHYL+BUTANOATE'>PIB</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7blo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7blo OCA], [https://pdbe.org/7blo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7blo RCSB], [https://www.ebi.ac.uk/pdbsum/7blo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7blo ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VP26A_HUMAN VP26A_HUMAN] Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922). Required for the endosomal localization of FAM21A (indicative for the WASH complex) (PubMed:22070227). Required for the endosomal localization of TBC1D5 (PubMed:20923837). Mediates retromer cargo reognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R (PubMed:16407403). Involved in recycling of ADRB2 (PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity).[UniProtKB:P40336]<ref>PMID:15078902</ref> <ref>PMID:15078903</ref> <ref>PMID:15247922</ref> <ref>PMID:16407403</ref> <ref>PMID:22070227</ref> <ref>PMID:22279231</ref> <ref>PMID:20923837</ref> <ref>PMID:21602791</ref> <ref>PMID:21725319</ref> <ref>PMID:23563491</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Retromer is a master regulator of cargo retrieval from endosomes, which is critical for many cellular processes including signaling, immunity, neuroprotection, and virus infection. The retromer core (VPS26/VPS29/VPS35) is present on cargo-transporting, tubular carriers along with a range of sorting nexins. Here, we elucidate the structural basis of membrane tubulation and coupled cargo recognition by metazoan and fungal retromer coats assembled with the non-Bin1/Amphiphysin/Rvs (BAR) sorting nexin SNX3 using cryo-electron tomography. The retromer core retains its arched, scaffolding structure but changes its mode of membrane recruitment when assembled with different SNX adaptors, allowing cargo recognition at subunit interfaces. Thus, membrane bending and cargo incorporation can be modulated to allow retromer to traffic cargoes along different cellular transport routes.
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Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly.,Leneva N, Kovtun O, Morado DR, Briggs JAG, Owen DJ Sci Adv. 2021 Mar 24;7(13):eabf8598. doi: 10.1126/sciadv.abf8598. Print 2021 Mar. PMID:33762348<ref>PMID:33762348</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7blo" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Sorting nexin 3D structures|Sorting nexin 3D structures]]
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*[[Vacuolar protein sorting-associated protein 3D structures|Vacuolar protein sorting-associated protein 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Mus musculus]]
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[[Category: Briggs JAG]]
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[[Category: Kovtun O]]
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[[Category: Leneva N]]
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[[Category: Morado DR]]
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[[Category: Owen DJ]]

Current revision

VPS26 dimer region of metazoan membrane-assembled retromer:SNX3 complex modelled with human proteins

PDB ID 7blo

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