8g33
From Proteopedia
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==Activated form of a CDCL long protein== | ==Activated form of a CDCL long protein== | ||
| - | <StructureSection load='8g33' size='340' side='right'caption='[[8g33]]' scene=''> | + | <StructureSection load='8g33' size='340' side='right'caption='[[8g33]], [[Resolution|resolution]] 2.49Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G33 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[8g33]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Elizabethkingia_anophelis_Ag1 Elizabethkingia anophelis Ag1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G33 FirstGlance]. <br> |
| - | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49Å</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g33 OCA], [https://pdbe.org/8g33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g33 RCSB], [https://www.ebi.ac.uk/pdbsum/8g33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g33 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g33 OCA], [https://pdbe.org/8g33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g33 RCSB], [https://www.ebi.ac.uk/pdbsum/8g33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g33 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A1T3IZT7_9FLAO A0A1T3IZT7_9FLAO] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Pore-forming proteins comprise a highly diverse group of proteins exemplified by the membrane attack complex/perforin (MACPF), cholesterol-dependent cytolysin (CDC), and gasdermin superfamilies, which all form gigantic pores (>150 angstroms). A recently found family of pore-forming toxins, called CDC-like proteins (CDCLs), are wide-spread in gut microbes and are a prevalent means of antibacterial antagonism. However, the structural aspects of how CDCLs assemble a pore remain a mystery. Here, we report the crystal structure of a proteolytically activated CDCL and cryo-electron microscopy structures of a prepore-like intermediate and a transmembrane pore providing detailed snapshots across the entire pore-forming pathway. These studies reveal a sophisticated array of regulatory features to ensure productive pore formation, and, thus, CDCLs straddle the MACPF, CDC, and gasdermin lineages of the giant pore superfamilies. | ||
| + | |||
| + | Structural basis for the pore-forming activity of a complement-like toxin.,Johnstone BA, Christie MP, Joseph R, Morton CJ, Brown HG, Hanssen E, Sanford TC, Abrahamsen HL, Tweten RK, Parker MW Sci Adv. 2025 Mar 28;11(13):eadt2127. doi: 10.1126/sciadv.adt2127. Epub 2025 Mar , 28. PMID:40153490<ref>PMID:40153490</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 8g33" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Elizabethkingia anophelis Ag1]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Christie MP]] |
| + | [[Category: Johnstone BA]] | ||
| + | [[Category: Morton CJ]] | ||
| + | [[Category: Parker MW]] | ||
Current revision
Activated form of a CDCL long protein
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