8wpa

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Current revision (11:07, 16 April 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8wpa is ON HOLD until 2026-04-09
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==Crystal Structure of the Acinetobacter baumannii LysR family regulator AceR DNA-binding domain (H32)==
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<StructureSection load='8wpa' size='340' side='right'caption='[[8wpa]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8wpa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii_ATCC_17978 Acinetobacter baumannii ATCC 17978]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WPA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WPA FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wpa OCA], [https://pdbe.org/8wpa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wpa RCSB], [https://www.ebi.ac.uk/pdbsum/8wpa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wpa ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACER_ACIBT ACER_ACIBT] Regulates the expression of the AceI transporter (PubMed:29481596). Binds DNA and chlorhexidine (PubMed:29481596, PubMed:32636271). Binds to regulatory sites within the intergenic region between the aceI and aceR genes, and affects the interaction between RNA polymerase (RNAP) and promoter DNA both in the presence and in the absence of chlorhexidine (PubMed:29481596, PubMed:32636271). In the absence of chlorhexidine, prevents transcription of the aceI gene by disrupting interactions between the promoter DNA and RNAP (PubMed:32636271). In the presence of chlorhexidine, activates expression of aceI (PubMed:29481596, PubMed:32636271). When AceR interacts with chlorhexidine, it undergoes a conformational change and the tetrameric form either releases the DNA or shifts the position of the DNA-binding region to allow RNAP to bind onto the promoter DNA to proceed with aceI transcription (PubMed:32636271).<ref>PMID:29481596</ref> <ref>PMID:32636271</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Acinetobacter baumannii ATCC 17978]]
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[[Category: Large Structures]]
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[[Category: Ge HH]]
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[[Category: Ma JM]]
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[[Category: Wang N]]

Current revision

Crystal Structure of the Acinetobacter baumannii LysR family regulator AceR DNA-binding domain (H32)

PDB ID 8wpa

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