9d0x

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Current revision (11:18, 16 April 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9d0x is ON HOLD until 2026-08-07
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==Cryo-EM structure of CDK2/CyclinE1 in complex with CRBN/DDB1 and Cpd 4 (local mask)==
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<StructureSection load='9d0x' size='340' side='right'caption='[[9d0x]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
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Authors: Kwiatkowski, N., Liang, T., Sha, Z., Collier, P.N., Yang, A., Sathappa, M., Paul, A., Su, L., Zheng, X., Aversa, R., Li, K., Mehovic, R., Breitkopf, S.B., Chen, D., Howarth, C.L., Yuan, K., Jo, H., Growney, J.D., Weiss, M., Williams, J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9d0x]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9D0X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9D0X FirstGlance]. <br>
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Description: Cryo-EM structure of CDK2/CyclinE1 in complex with CRBN/DDB1 and Cpd 4 (local mask)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.84&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1A1I:(3~{R})-3-[5-[4-[[2-[4-[(8-cyclopentyl-7-oxidanylidene-pyrido[2,3-d]pyrimidin-2-yl)amino]-3-methyl-phenyl]sulfonyl-7-azaspiro[3.5]nonan-7-yl]methyl]piperidin-1-yl]-4-fluoranyl-3-methyl-2-oxidanylidene-benzimidazol-1-yl]piperidine-2,6-dione'>A1A1I</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Aversa, R]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9d0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9d0x OCA], [https://pdbe.org/9d0x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9d0x RCSB], [https://www.ebi.ac.uk/pdbsum/9d0x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9d0x ProSAT]</span></td></tr>
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[[Category: Kwiatkowski, N]]
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</table>
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[[Category: Howarth, C.L]]
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== Disease ==
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[[Category: Su, L]]
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[https://www.uniprot.org/uniprot/CRBN_HUMAN CRBN_HUMAN] Autosomal recessive nonsyndromic intellectual deficit;Distal monosomy 3p. The disease is caused by mutations affecting the gene represented in this entry.
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[[Category: Liang, T]]
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== Function ==
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[[Category: Sha, Z]]
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[https://www.uniprot.org/uniprot/CRBN_HUMAN CRBN_HUMAN] Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1.<ref>PMID:18414909</ref> <ref>PMID:20223979</ref>
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[[Category: Breitkopf, S.B]]
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== References ==
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[[Category: Yang, A]]
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<references/>
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[[Category: Chen, D]]
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__TOC__
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[[Category: Sathappa, M]]
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</StructureSection>
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[[Category: Paul, A]]
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[[Category: Homo sapiens]]
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[[Category: Williams, J]]
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[[Category: Large Structures]]
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[[Category: Zheng, X]]
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[[Category: Aversa R]]
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[[Category: Li, K]]
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[[Category: Breitkopf SB]]
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[[Category: Jo, H]]
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[[Category: Chen D]]
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[[Category: Weiss, M]]
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[[Category: Collier PN]]
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[[Category: Collier, P.N]]
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[[Category: Growney JD]]
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[[Category: Yuan, K]]
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[[Category: Howarth CL]]
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[[Category: Growney, J.D]]
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[[Category: Jo H]]
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[[Category: Mehovic, R]]
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[[Category: Kwiatkowski N]]
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[[Category: Li K]]
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[[Category: Liang T]]
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[[Category: Mehovic R]]
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[[Category: Paul A]]
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[[Category: Sathappa M]]
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[[Category: Sha Z]]
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[[Category: Su L]]
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[[Category: Weiss M]]
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[[Category: Williams J]]
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[[Category: Yang A]]
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[[Category: Yuan K]]
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[[Category: Zheng X]]

Current revision

Cryo-EM structure of CDK2/CyclinE1 in complex with CRBN/DDB1 and Cpd 4 (local mask)

PDB ID 9d0x

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