9ms2
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human CYP3A5 in complex with SJYHJ-111== | |
| - | + | <StructureSection load='9ms2' size='340' side='right'caption='[[9ms2]], [[Resolution|resolution]] 2.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9ms2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MS2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BNX:3-(2-chlorophenyl)-1-[(3-hydroxyphenyl)methyl]-1-[2-imidazol-1-yl-5-(trifluoromethyl)phenyl]urea'>A1BNX</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ms2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ms2 OCA], [https://pdbe.org/9ms2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ms2 RCSB], [https://www.ebi.ac.uk/pdbsum/9ms2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ms2 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/CP3A5_HUMAN CP3A5_HUMAN] Tacrolimus dose selection. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CP3A5_HUMAN CP3A5_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chen T]] | ||
| + | [[Category: Jingheng W]] | ||
| + | [[Category: Miller DJ]] | ||
| + | [[Category: Nithianantham S]] | ||
Revision as of 11:32, 16 April 2025
Crystal structure of human CYP3A5 in complex with SJYHJ-111
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