User:Peyton Jenkins/Sandbox 1
From Proteopedia
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<StructureSection load='8vsu' size='340' side='right' caption='Heterotrimeric Complex of STK11, MO25, STRADα' scene=''> | <StructureSection load='8vsu' size='340' side='right' caption='Heterotrimeric Complex of STK11, MO25, STRADα' scene=''> | ||
== Relevance and Disease == | == Relevance and Disease == | ||
| - | Lung cancer is the leading cause of cancer related death worldwide. In the United States alone, over 120,000 deaths were caused by lung cancer in 2024<ref>https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2024/2024-cancer-facts-and-figures-acs.pdf</ref>. Non small cell lung cancer make up approximately 84% of all lung cancer cases, and of these lung adenocarcinoma accounts for about 65%<ref>10.1001/jamaoncol.2021.4932</ref>. In lung adenocarcinoma, STK11 is the third most commonly mutated gene, behind only KRAS and p53<ref>10.1091/mbc.E15-08-0569.</ref> | + | Lung cancer is the leading cause of cancer related death worldwide. In the United States alone, over 120,000 deaths were caused by lung cancer in 2024<ref>https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2024/2024-cancer-facts-and-figures-acs.pdf</ref>. Non small cell lung cancer make up approximately 84% of all lung cancer cases, and of these lung adenocarcinoma accounts for about 65%<ref>10.1001/jamaoncol.2021.4932</ref>. In lung adenocarcinoma, ''STK11'' is the third most commonly mutated gene, behind only ''KRAS'' and ''p53''<ref>10.1091/mbc.E15-08-0569.</ref>. |
== Structural Highlights == | == Structural Highlights == | ||
The heterotrimeric complex is composed of <scene name='10/1078094/Heterotrimeric_complex/1'>STK11, Mo25, and STRADα</scene> | The heterotrimeric complex is composed of <scene name='10/1078094/Heterotrimeric_complex/1'>STK11, Mo25, and STRADα</scene> | ||
Revision as of 21:13, 22 April 2025
8VSU: Heterotrimeric Complex of STK11, Mo25, and STRADa
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