1vlk

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[[Image:1vlk.gif|left|200px]]
[[Image:1vlk.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vlk OCA], [http://www.ebi.ac.uk/pdbsum/1vlk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1vlk RCSB]</span>
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'''STRUCTURE OF VIRAL INTERLEUKIN-10'''
'''STRUCTURE OF VIRAL INTERLEUKIN-10'''
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[[Category: Wlodawer, A.]]
[[Category: Wlodawer, A.]]
[[Category: Zdanov, A.]]
[[Category: Zdanov, A.]]
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[[Category: cytokine]]
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[[Category: Cytokine]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: signal]]
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[[Category: Signal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:41:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:26:07 2008''
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Revision as of 09:41, 3 May 2008

Image:1vlk.gif

Template:STRUCTURE 1vlk

STRUCTURE OF VIRAL INTERLEUKIN-10


Overview

The crystal structure of Epstein-Barr virus protein BCRF1, an analog of cellular interleukin-10 (IL-10), has been determined at the resolution of 1.9 A and refined to an R-factor 0.191. The structure of this cytokine is similar to that of human IL-10 (hIL-10), forming an intercalated dimer of two 17 kDa polypeptides related by a crystallographic 2-fold symmetry axis. BCRF1 exhibits novel conformations of the N-terminal coil and of the loop between helices A and B compared to hIL-10. These regions are likely to be involved in binding of one or more components of the IL-10 receptor system, and thus the structural differences may account for the lower binding affinity and limited spectrum of biological activities of viral IL-10, compared to hIL-10.

About this Structure

1VLK is a Single protein structure of sequence from Human herpesvirus 4. Full crystallographic information is available from OCA.

Reference

Crystal structure of Epstein-Barr virus protein BCRF1, a homolog of cellular interleukin-10., Zdanov A, Schalk-Hihi C, Menon S, Moore KW, Wlodawer A, J Mol Biol. 1997 May 2;268(2):460-7. PMID:9159483 Page seeded by OCA on Sat May 3 12:41:06 2008

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OCA

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