8qsd

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:14, 23 April 2025) (edit) (undo)
 
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8qsd is ON HOLD until Paper Publication
+
==Ternary structure of 14-3-3s, BRAF phosphopeptide (pS365) and compound 79 (1124379).==
-
 
+
<StructureSection load='8qsd' size='340' side='right'caption='[[8qsd]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
Authors: Konstantinidou, M., Vickery, H., Pennings, M.A.M., Virta, J., Visser, E.J., Oetelaar, M.C.M., Overmans, M., Neitz, J., Ottmann, C., Brunsveld, L., Arkin, M.R.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8qsd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QSD FirstGlance]. <br>
-
Description: Ternary structure of 14-3-3s, BRAF phosphopeptide (pS365) and compound 79 (1124379).
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=WQT:2-chloranyl-1-[8-(4-iodophenyl)sulfonyl-5-oxa-2,8-diazaspiro[3.5]nonan-2-yl]ethanone'>WQT</scene></td></tr>
-
[[Category: Overmans, M]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qsd OCA], [https://pdbe.org/8qsd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qsd RCSB], [https://www.ebi.ac.uk/pdbsum/8qsd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qsd ProSAT]</span></td></tr>
-
[[Category: Konstantinidou, M]]
+
</table>
-
[[Category: Arkin, M.R]]
+
== Function ==
-
[[Category: Visser, E.J]]
+
[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
-
[[Category: Pennings, M.A.M]]
+
__TOC__
-
[[Category: Virta, J]]
+
</StructureSection>
-
[[Category: Ottmann, C]]
+
[[Category: Homo sapiens]]
-
[[Category: Oetelaar, M.C.M]]
+
[[Category: Large Structures]]
-
[[Category: Neitz, J]]
+
[[Category: Arkin MR]]
-
[[Category: Vickery, H]]
+
[[Category: Brunsveld L]]
-
[[Category: Brunsveld, L]]
+
[[Category: Konstantinidou M]]
 +
[[Category: Neitz J]]
 +
[[Category: Oetelaar MCM]]
 +
[[Category: Ottmann C]]
 +
[[Category: Overmans M]]
 +
[[Category: Pennings MAM]]
 +
[[Category: Vickery H]]
 +
[[Category: Virta J]]
 +
[[Category: Visser EJ]]

Current revision

Ternary structure of 14-3-3s, BRAF phosphopeptide (pS365) and compound 79 (1124379).

PDB ID 8qsd

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8qsd"
Personal tools