9bub
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human calcitonin Receptor in complex with Gs and cagrilintide in the bypass conformation== | |
| - | + | <StructureSection load='9bub' size='340' side='right'caption='[[9bub]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9bub]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9BUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9BUB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.3Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1B90:icosanedioic+acid'>A1B90</scene>, <scene name='pdbligand=GGL:GAMMA-L-GLUTAMIC+ACID'>GGL</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=P42:(2S)-2-{[(1R)-1-HYDROXYHEXADECYL]OXY}-3-{[(1R)-1-HYDROXYOCTADECYL]OXY}PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>P42</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9bub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9bub OCA], [https://pdbe.org/9bub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9bub RCSB], [https://www.ebi.ac.uk/pdbsum/9bub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9bub ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CALCR_HUMAN CALCR_HUMAN] This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Lama glama]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Belousoff MJ]] | ||
| + | [[Category: Cao J]] | ||
| + | [[Category: Johnson RM]] | ||
| + | [[Category: Sexton PM]] | ||
| + | [[Category: Wootten DL]] | ||
Current revision
Human calcitonin Receptor in complex with Gs and cagrilintide in the bypass conformation
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