9m0s

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Current revision (05:33, 23 April 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9m0s is ON HOLD until Paper Publication
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==Acetyl-CoA-bound SLC33A1 in a cytoplasm-facing conformation==
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<StructureSection load='9m0s' size='340' side='right'caption='[[9m0s]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9m0s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9M0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9M0S FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9m0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9m0s OCA], [https://pdbe.org/9m0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9m0s RCSB], [https://www.ebi.ac.uk/pdbsum/9m0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9m0s ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ACATN_HUMAN ACATN_HUMAN] Congenital cataract-hearing loss-severe developmental delay syndrome;Autosomal dominant spastic paraplegia type 42. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/ACATN_HUMAN ACATN_HUMAN] Acetyl-CoA transporter that mediates active acetyl-CoA import through the endoplasmic reticulum (ER) membrane into the ER lumen where specific ER-based acetyl-CoA:lysine acetyltransferases are responsible for the acetylation of ER-based protein substrates, such as BACE1 (PubMed:20826464, PubMed:24828632). Necessary for O-acetylation of gangliosides (PubMed:9096318).<ref>PMID:20826464</ref> <ref>PMID:24828632</ref> <ref>PMID:25402622</ref> <ref>PMID:9096318</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Zhang Z]]
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[[Category: Zhou D]]

Current revision

Acetyl-CoA-bound SLC33A1 in a cytoplasm-facing conformation

PDB ID 9m0s

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